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Cul2 [cytosol]
Stable Identifier
R-MMU-416982
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
CUL2, Q9D4H8
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to hypoxia (Mus musculus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Mus musculus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Mus musculus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
Proteasome proteolyzes ub-HIF-alpha (Mus musculus)
VBC complex (with or without LIMD1) [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Mus musculus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Mus musculus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Class I MHC mediated antigen processing & presentation (Mus musculus)
Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
Polyubiquitination of substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
Release of E3 from polyubiquitinated substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Neddylation (Mus musculus)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Mus musculus)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Mus musculus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9D4H8
Gene Names
Cul2
Reference Genes
BioGPS Gene:71745 Cul2
ENSEMBL:ENSMUSG00000024231
ENSEMBL:ENSMUSG00000024231.16 Cul2
KEGG Gene (Mus musculus):71745 Cul2
Monarch:71745 Cul2
NCBI Gene:71745 Cul2
UCSC:Q9D4H8 Cul2
Reference Transcript
RefSeq:XM_006526275.3 Cul2
RefSeq:NM_029402.3 Cul2
RefSeq:XM_006526274.3 Cul2
Other Identifiers
10453575
136193_i_at
136194_f_at
1419765_at
1451231_a_at
17348079
4333337
4360294
4418663
4449833
4470170
4470251
4633819
4687238
4729844
4775929
4790852
4798312
4873500
4969325
4979751
5109796
5116732
5167420
5204576
5286873
5341691
5414716
5415041
5510073
5540296
5573862
5591771
5602244
71745
96232_at
A_51_P496448
A_52_P483544
A_55_P2121076
A_55_P2121081
A_55_P2121082
A_55_P2168417
GE124962
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0006511
GO:0016567
GO:0019005
GO:0019538
GO:0030163
GO:0030674
GO:0030891
GO:0031146
GO:0031461
GO:0031462
GO:0031625
GO:0036211
GO:0043226
GO:0044877
GO:0060090
GO:0140627
GO:0160072
ILMN_1238615
ILMN_1247069
ILMN_2987369
aa182283_s_at
mMC017638
Participates
as a component of
CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
Other forms of this molecule
Cul2 [cytosol]
Cul2 [nucleoplasm]
Inferred From
CUL2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006526337.1
,
XP_006526338.1
,
NP_083678.2
Ensembl
ENSMUST00000162301
,
ENSMUSG00000024231
,
ENSMUSP00000125403
,
ENSMUST00000025073
,
ENSMUSP00000025073
PRO
Q9D4H8
MGI
1918995
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