Reactome | Src [cytosol]

Src [cytosol]

Stable Identifier

R-MMU-418782

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Neuronal proto-oncogene tyrosine-protein kinase Src, SRC_MOUSE, Src

External Reference Information

External Reference

UniProt:P05480 Src

Gene Names

Src

Chain

initiator methionine:1, chain:2-541

Reference Genes

BioGPS Gene:20779 Src

ENSEMBL:ENSMUSG00000027646 Src

KEGG Gene (Mus musculus):20779 Src

Monarch:20779 Src

NCBI Gene:20779 Src

UCSC:P05480 Src

Reference Transcript

Other Identifiers

10477970

108711_at

1423240_at

1450918_s_at

17378721

20779

4447733

4804560

4812643

4829346

5034979

5043570

5059963

5091749

5135638

5152044

5258840

5302244

5305028

5374549

5400005

5430370

5495801

99388_at

A_52_P600547

GE33726

GO:0000003

GO:0000166

GO:0000902

GO:0001545

GO:0002102

GO:0002376

GO:0003013

GO:0003674

GO:0004672

GO:0004713

GO:0004715

GO:0005080

GO:0005102

GO:0005158

GO:0005178

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005743

GO:0005764

GO:0005768

GO:0005770

GO:0005773

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005901

GO:0005925

GO:0005975

GO:0006259

GO:0006464

GO:0006468

GO:0006629

GO:0006810

GO:0006950

GO:0007010

GO:0007049

GO:0007155

GO:0007165

GO:0007169

GO:0007173

GO:0007179

GO:0007229

GO:0007267

GO:0008022

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0009058

GO:0009612

GO:0009615

GO:0010447

GO:0010628

GO:0010632

GO:0010634

GO:0010641

GO:0010907

GO:0010954

GO:0014069

GO:0014911

GO:0015031

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0018105

GO:0018108

GO:0019899

GO:0019900

GO:0019901

GO:0019904

GO:0020037

GO:0022407

GO:0022607

GO:0030054

GO:0030154

GO:0030331

GO:0030900

GO:0031234

GO:0031333

GO:0031410

GO:0031625

GO:0031648

GO:0031667

GO:0031954

GO:0032148

GO:0032211

GO:0032587

GO:0032869

GO:0033146

GO:0034330

GO:0034332

GO:0034446

GO:0034614

GO:0034641

GO:0035306

GO:0035556

GO:0036035

GO:0036120

GO:0038083

GO:0040007

GO:0040011

GO:0042127

GO:0042169

GO:0042476

GO:0042493

GO:0042542

GO:0042592

GO:0043005

GO:0043065

GO:0043066

GO:0043149

GO:0043154

GO:0043167

GO:0043226

GO:0043393

GO:0043406

GO:0043552

GO:0044281

GO:0044325

GO:0044877

GO:0045056

GO:0045087

GO:0045453

GO:0045737

GO:0045747

GO:0045785

GO:0045892

GO:0045893

GO:0046628

GO:0046777

GO:0046875

GO:0048011

GO:0048041

GO:0048471

GO:0048477

GO:0048856

GO:0048870

GO:0050715

GO:0050731

GO:0050839

GO:0050847

GO:0050877

GO:0051057

GO:0051219

GO:0051222

GO:0051276

GO:0051385

GO:0051602

GO:0051604

GO:0051895

GO:0051897

GO:0051902

GO:0051974

GO:0060065

GO:0060444

GO:0060491

GO:0060576

GO:0065003

GO:0070102

GO:0070301

GO:0070374

GO:0070542

GO:0070555

GO:0070700

GO:0070851

GO:0071222

GO:0071253

GO:0071375

GO:0071393

GO:0071398

GO:0071456

GO:0071498

GO:0071560

GO:0071803

GO:0071902

GO:0086098

GO:0090263

GO:0097110

GO:0098609

GO:0098962

GO:0098978

GO:0099091

GO:1900182

GO:1902533

GO:2000386

GO:2000394

GO:2000573

GO:2000588

GO:2000641

GO:2000811

GO:2001237

GO:2001243

GO:2001286

ILMN_1254757

ILMN_2638454

ILMN_2638455

ILMN_3148543

Msa.1184.0_at

mMC016824

Participant Of

hasComponent

input

G alpha (i):GTP binds Src

hasMember

Src family kinases (SFKs) [cytosol]

Other forms of this molecule

Src [cytosol]

phospho-Src [cytosol]

phospho-Src [plasma membrane]

Src [plasma membrane]

phospho-Src [plasma membrane]

Activated Src [nucleoplasm]

Src [plasma membrane]

MyrG-p-Y424-Src [plasma membrane]

phospho-Src [cytosol]

Src [cytosol]

Cross References

RefSeq

NP_001020566.1, NP_033297.2

ZINC - Substances

SRC_MOUSE

Ensembl

ENSMUSP00000105155, ENSMUSP00000090237, ENSMUSG00000027646, ENSMUST00000109529, ENSMUST00000092576

ZINC target

P05480

PRO

P05480

MGI

98397

ZINC - Predictions - Purchasable

SRC_MOUSE

PDB

6F3F

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q05397 PTK2	11	p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.683	5
UniProt:P31016 Dlg4	3	Dlg4 [cytosol] (R-RNO-6794248) Dlg4 [endocytic vesicle membrane] (R-RNO-416847) Dlg4 [plasma membrane] (R-RNO-9612601)	0.645	9
UniProt:P19367 HK1	4	HK1 577-672del [cytosol] (R-HSA-5621873) HK1 T680S [cytosol] (R-HSA-5621880) HK1 L529S [cytosol] (R-HSA-5621861) HK1 [cytosol] (R-HSA-70395)	0.644	8
UniProt:P35438 Grin1	3	Grin1 [endoplasmic reticulum membrane] (R-MMU-9610359) Grin1 [plasma membrane] (R-MMU-3928395) Grin1 [transport vesicle membrane] (R-MMU-9610566)	0.643	4
UniProt:Q01973 ROR1	2	ROR1 [plasma membrane] (R-HSA-197814) ROR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140727)	0.602	3
UniProt:P52789 HK2	1	HK2 [cytosol] (R-HSA-70378)	0.602	4
UniProt:Q13507-3 TRPC3			0.602	4
UniProt:P05106 ITGB3	3	ITGB3(27-?) [platelet alpha granule membrane] (R-HSA-114512) p-T779-ITGB3 [plasma membrane] (R-HSA-432107) ITGB3 [plasma membrane] (R-HSA-57600)	0.602	5
UniProt:O70469	1	Dok2 [cytosol] (R-MMU-204823)	0.591	4
UniProt:Q00959 Grin2a	3	p-Y-Grin2a [plasma membrane] (R-RNO-9628245) Grin2a [endoplasmic reticulum membrane] (R-RNO-9609845) Grin2a [plasma membrane] (R-RNO-6794271)	0.558	5
UniProt:Q9CQV6	3	Map1lc3b [cytosol] (R-MMU-5682674) Map1lc3b [autophagosome membrane] (R-MMU-5683641) Map1lc3b [cytosol] (R-MMU-5205651)	0.528	2
UniProt:P70315 Was	1	Wasp [cytosol] (R-MMU-2029026)	0.524	2
UniProt:P07141	3	Csf1 [endoplasmic reticulum lumen] (R-MMU-8956778) phospho-Csf1 [endoplasmic reticulum lumen] (R-MMU-8956881) Csf1 [extracellular region] (R-MMU-9009484)	0.524	2
UniProt:Q63767	4	phospho-Bcar1 [cytosol] (R-RNO-5218739) phospho-Bcar1 [cytosol] (R-RNO-372645) phospho-Bcar1 [cytosol] (R-RNO-8848723) Bcar1 [cytosol] (R-RNO-201625)	0.524	2
UniProt:P23242	6	Gja1 [endoplasmic reticulum membrane] (R-MMU-190654) Gja1 [Golgi membrane] (R-MMU-190649) Gja1 [lysosomal membrane] (R-MMU-196173) phospho-Gja1 [plasma membrane] (R-MMU-191657) Gja1 [Golgi-associated vesicle membrane] (R-MMU-190544) Gja1 [plasma membrane] (R-MMU-158058)	0.499	3
UniProt:P31750 Akt1	10	p-T308,S473-Akt1 [cytosol] (R-MMU-162346) p-T308,S473-Akt1 [plasma membrane] (R-MMU-1445123) phospho-Akt1 [plasma membrane] (R-MMU-199430) phospho-Akt1 [cytosol] (R-MMU-8848757) phospho-Akt1 [cytosol] (R-MMU-198634) phospho-Akt1 [nucleoplasm] (R-MMU-198357) Akt1 [cytosol] (R-MMU-58252) Akt1 [plasma membrane] (R-MMU-199416) phospho-Akt1 [plasma membrane] (R-MMU-377265) phospho-Akt1 [cytosol] (R-MMU-198356)	0.499	3
UniProt:P35546	2	phospho-Ret [plasma membrane] (R-MMU-8854162) Ret [plasma membrane] (R-MMU-8853797)	0.463	2
UniProt:P54763 Ephb2	9	p-Ephb2 [plasma membrane] (R-MMU-3928433) phospho-Ephb2 [plasma membrane] (R-MMU-3928375) Ephb2 [plasma membrane] (R-MMU-443809) Ephb2 [extracellular region] (R-MMU-3928436) Ephb2 [plasma membrane] (R-MMU-3928386) Ephb2 [cytosol] (R-MMU-3928432) Ephb2 [plasma membrane] (R-MMU-3928394) Ephb2 [plasma membrane] (R-MMU-3928443) p-Y604,Y610-Ephb2 [plasma membrane] (R-MMU-4093312)	0.463	3

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