Shp2 binds pUnc5C

Stable Identifier
R-MMU-418862
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Shp2 binds pUnc5C
PTPN11 (SHP2) is recruited to the phosphorylated UNC5C receptor after netrin-1 (NTN1) stimulation, in a fashion that requires binding of the PTPN11 SH2 domains to the Tyr568 (Y568) phosphorylated motif. The functional significance of the UNC5C- PTPN11 interaction has not been reported. PTPN11 might negatively regulate tyrosine phosphorylation of UNC5C receptor, facilitating resensitization of the receptor to the netrin-1 signal.
Literature References
PubMed ID Title Journal Year
17254765 Netrin signaling leading to directed growth cone steering

Round, J, Stein, E

Curr Opin Neurobiol 2007
11533026 Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain

Pawson, T, Steven, R, Killeen, M, Culotti, J, Tong, J, Binns, KL

J Biol Chem 2001
Participants
Input
Output
Orthologous Events
Shp2 binds pUnc5C (Homo sapiens)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-04-27)
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