Unc5h1 binds NRAGE

Stable Identifier
R-MMU-418871
Type
Reaction
Species
Mus musculus
Compartment
General
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Unc5h1 binds NRAGE

The neurotrophin receptor-interacting melanoma-associated antigen (MAGE) homologue, NRAGE, known to be a regulator of apoptosis, has been identified as a specific binding partner of UNC5H1. NRAGE utilizes two mechanisms to induce UNC5H1mediated apoptosis in cells: first, through the degradation of the caspase inhibitor X-chromosome-linked inhibitor of apoptosis protein (XIAP), and second, through the activation of the proapoptotic c-JUN N-terminal kinase (JNK) signaling pathway.

Literature References
PubMed ID Title Journal Year
17449433 Dependence receptors: when apoptosis controls tumor progression

Bernet, A, Mehlen, P

Bull Cancer 2007
15573119 Netrin-1 and its receptors in tumorigenesis

Arakawa, H

Nat Rev Cancer 2004
12598531 UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE

Williams, ME, Strickland, P, Watanabe, K, Hinck, L

J Biol Chem 2003
Participants
Orthologous Events
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