Reactome | Faap24 [nucleoplasm]

Faap24 [nucleoplasm]

Stable Identifier

R-MMU-419533

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

FAAP24, Q8BHL6

Locations in the PathwayBrowser

Expand all

DNA Repair (Mus musculus)

- Fanconi Anemia Pathway (Mus musculus)
  - ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Mus musculus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Mus musculus)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex [nucleoplasm] (Mus musculus)
        
        FANCM:FAAP24 [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
  - DNA nucleases bind monoubiquitinated ID2 complex (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Mus musculus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Mus musculus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Mus musculus)
      - FA core complex [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
  - FA core complex assembles at DNA interstrand crosslinks (ICLs) (Mus musculus)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - FA Core Complex [nucleoplasm] (Mus musculus)
        
        FANCM:FAAP24 [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
    - FANCM:FAAP24:APITD1:STRA13:ICL-DNA [nucleoplasm] (Mus musculus)
      - FANCM:FAAP24 [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
  - FANCD2 deubiquitination by USP1:WDR48 (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
    - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
  - FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Mus musculus)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - FA Core Complex [nucleoplasm] (Mus musculus)
        
        FANCM:FAAP24 [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex [nucleoplasm] (Mus musculus)
        
        FANCM:FAAP24 [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
  - FANCM binds FAAP24 (Mus musculus)
    - FANCM:FAAP24 [nucleoplasm] (Mus musculus)
      - Faap24 [nucleoplasm] (Mus musculus)
    - Faap24 [nucleoplasm] (Mus musculus)
  - Monoubiquitination of FANCD2:FANCI (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
  - POLN binds ICL-DNA (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Mus musculus)
      - FA core complex [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Mus musculus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA core complex [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
  - The complex of ATR and ATRIP is recruited to ICL-DNA (Mus musculus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex [nucleoplasm] (Mus musculus)
        
        FANCM:FAAP24 [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Mus musculus)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex [nucleoplasm] (Mus musculus)
        
        FANCM:FAAP24 [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
  - Translesion synthesis across unhooked ICL by POLN (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Mus musculus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA core complex [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)
    - p-FA Core Complex [nucleoplasm] (Mus musculus)
      - p-S1045-FANCM:FAAP24 [nucleoplasm] (Mus musculus)
        
        Faap24 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8BHL6

Gene Names

Faap24

Reference Genes

BioGPS Gene:101831 Faap24

ENSEMBL:ENSMUSG00000030493

ENSEMBL:ENSMUSG00000030493.14 Faap24

KEGG Gene (Mus musculus):101831 Faap24

Monarch:101831 Faap24

NCBI Gene:101831 Faap24

UCSC:Q8BHL6 Faap24

Reference Transcript

RefSeq:NM_178643.5 Faap24

Other Identifiers

101831

10562461

115367_at

1454779_s_at

17489759

4360619

4568629

4622781

4634900

4661252

4704894

5126399

5183871

5338287

A_52_P426863

A_66_P116444

GO:0000785

GO:0003677

GO:0003682

GO:0005634

GO:0005654

GO:0005694

GO:0006281

GO:0006974

GO:0036297

GO:0043226

GO:0043231

GO:0043240

GO:0071821

ILMN_1216046

ILMN_2994631

aa415484_rc_at

mMC014133

Participates

as a component of

as an input of

FANCM binds FAAP24 (Mus musculus)

Other forms of this molecule

Faap24 [cytosol]

Inferred From

FAAP24 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_848758.1

Ensembl

ENSMUSG00000030493, ENSMUSP00000032704, ENSMUST00000154597, ENSMUSP00000115766, ENSMUST00000032704

PRO

Q8BHL6

MGI

2142208

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