Reactome | Iapp [extracellular region]

Iapp [extracellular region]

Stable Identifier

R-MMU-420076

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

IAPP(34-70), P12968

Locations in the PathwayBrowser

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Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (s) signalling events (Mus musculus)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Mus musculus)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Mus musculus)
        
        AMY1-3:IAPP(34-70) [plasma membrane] (Mus musculus)
        
        Iapp [extracellular region] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Mus musculus)
        
        AMY1-3:IAPP(34-70) [plasma membrane] (Mus musculus)
        
        Iapp [extracellular region] (Mus musculus)
  - GPCR ligand binding (Mus musculus)
    - Class B/2 (Secretin family receptors) (Mus musculus)
      - Calcitonin-like ligand receptors (Mus musculus)
        
        AMY1-3 bind IAPP(34-70) (Mus musculus)
        
        AMY1-3:IAPP(34-70) [plasma membrane] (Mus musculus)
        
        Iapp [extracellular region] (Mus musculus)
        
        Iapp [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:P12968 Iapp

Gene Names

Iapp

Chain

signal peptide:1-23, propeptide:24-35, peptide:38-74, propeptide:78-93

Reference Genes

BioGPS Gene:15874 Iapp

KEGG:mmu:15874 Iapp

Monarch:15874 Iapp

NCBI Gene:15874 Iapp

UCSC:P12968 Iapp

Reference Transcript

RefSeq:NM_010491.2 Iapp

Other Identifiers

10542632

1423509_a_at

1423510_at

1437323_a_at

1456004_x_at

15874

17464102

4471722

4611502

4839985

4889909

4950141

5214271

99488_at

A_66_P114856

GO:0005102

GO:0005179

GO:0005576

GO:0005615

GO:0005829

GO:0007189

GO:0010739

GO:0019233

GO:0030154

GO:0030316

GO:0042755

GO:0042802

GO:0045453

GO:0045671

GO:0045779

GO:0048018

GO:0050850

GO:0050877

GO:0097647

GO:0098772

ILMN_1248774

ILMN_2996479

m25389_s_at

mMC008432

Participates

as an input of

AMY1-3 bind IAPP(34-70) (Mus musculus)

as a component of

AMY1-3:IAPP(34-70) [plasma membrane] (Mus musculus)

Other forms of this molecule

iapp [cytosol]

Inferred From

IAPP(34-70) [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_034621.1

ENSEMBL

ENSMUSG00000041681, ENSMUSP00000043956, ENSMUST00000041993

PRO

P12968

MGI

96382

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