Reactome | GRM2 [plasma membrane]

GRM2 [plasma membrane]

Stable Identifier

R-MMU-420468

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

Q14BI2

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (i) signalling events (Mus musculus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Mus musculus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Mus musculus)
        
        GRM2 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Mus musculus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Mus musculus)
        
        GRM2 [plasma membrane] (Mus musculus)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Mus musculus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Mus musculus)
        
        GRM2 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Mus musculus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Mus musculus)
        
        GRM2 [plasma membrane] (Mus musculus)
      - The Ligand:GPCR:Gi complex dissociates (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Mus musculus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Mus musculus)
        
        GRM2 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Mus musculus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Mus musculus)
        
        GRM2 [plasma membrane] (Mus musculus)
  - GPCR ligand binding (Mus musculus)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Mus musculus)
      - Metabotropic glutamate receptors bind glutamate (Mus musculus)
        
        GRM1-8 [plasma membrane] (Mus musculus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Mus musculus)
        
        GRM2 [plasma membrane] (Mus musculus)
        
        GRM1-8:L-Glu [plasma membrane] (Mus musculus)
        
        GRM1-8 [plasma membrane] (Mus musculus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Mus musculus)
        
        GRM2 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q14BI2

Reference Genes

BioGPS Gene:108068

ENSEMBL:ENSMUSG00000023192

ENSEMBL:ENSMUSG00000023192.13

KEGG Gene (Mus musculus):108068

Monarch:108068

NCBI Gene:108068

UCSC:Q14BI2

Reference Transcript

RefSeq:NM_001160353.1

Other Identifiers

10596521

108068

1435607_at

17530733

4337108

4419293

4426578

4442562

4502948

4523096

4561070

4644926

4698935

5300984

5381667

5573795

5598418

A_52_P342888

A_55_P2171348

GE102225

GO:0001641

GO:0004930

GO:0005246

GO:0005886

GO:0007154

GO:0007165

GO:0007186

GO:0007196

GO:0007215

GO:0007216

GO:0010467

GO:0014047

GO:0014048

GO:0014059

GO:0016020

GO:0023052

GO:0030424

GO:0030425

GO:0035095

GO:0042220

GO:0042734

GO:0042995

GO:0043005

GO:0045202

GO:0051896

GO:0051897

GO:0051966

GO:0060089

GO:0060292

GO:0090461

GO:0097110

GO:0097449

GO:0098772

GO:0098978

GO:0099171

GO:2001023

ILMN_1221677

ILMN_1230656

mMC017521

Participates

as a member of

GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Mus musculus)

Inferred From

GRM2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001153825.1

Ensembl

ENSMUST00000023959, ENSMUSG00000023192, ENSMUSP00000023959

PRO

Q14BI2

MGI

1351339

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