Reactome | GRM5 [plasma membrane]

GRM5 [plasma membrane]

Stable Identifier

R-MMU-420553

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

Q3UVX5

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (q) signalling events (Mus musculus)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        Group I Metabotropic glutamate receptors:Glu [plasma membrane] (Mus musculus)
        
        GRM1,GRM5 [plasma membrane] (Mus musculus)
        
        GRM5 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        Group I Metabotropic glutamate receptors:Glu [plasma membrane] (Mus musculus)
        
        GRM1,GRM5 [plasma membrane] (Mus musculus)
        
        GRM5 [plasma membrane] (Mus musculus)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        Group I Metabotropic glutamate receptors:Glu [plasma membrane] (Mus musculus)
        
        GRM1,GRM5 [plasma membrane] (Mus musculus)
        
        GRM5 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        Group I Metabotropic glutamate receptors:Glu [plasma membrane] (Mus musculus)
        
        GRM1,GRM5 [plasma membrane] (Mus musculus)
        
        GRM5 [plasma membrane] (Mus musculus)
      - The Ligand:GPCR:Gq complex dissociates (Mus musculus)
        
        GPCRs that activate Gq/11 [plasma membrane] (Mus musculus)
        
        GRM1,GRM5 [plasma membrane] (Mus musculus)
        
        GRM5 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        Group I Metabotropic glutamate receptors:Glu [plasma membrane] (Mus musculus)
        
        GRM1,GRM5 [plasma membrane] (Mus musculus)
        
        GRM5 [plasma membrane] (Mus musculus)
  - GPCR ligand binding (Mus musculus)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Mus musculus)
      - Metabotropic glutamate receptors bind glutamate (Mus musculus)
        
        GRM1-8 [plasma membrane] (Mus musculus)
        
        GRM1,GRM5 [plasma membrane] (Mus musculus)
        
        GRM5 [plasma membrane] (Mus musculus)
        
        GRM1-8:L-Glu [plasma membrane] (Mus musculus)
        
        GRM1-8 [plasma membrane] (Mus musculus)
        
        GRM1,GRM5 [plasma membrane] (Mus musculus)
        
        GRM5 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q3UVX5

Reference Genes

BioGPS Gene:108071

ENSEMBL:ENSMUSG00000049583

KEGG:mmu:108071

Monarch:108071

NCBI Gene:108071

UCSC:Q3UVX5

Reference Transcript

Other Identifiers

10554778

105897_at

108071

1443410_at

1455272_at

1456119_at

17480002

4868335

5052947

5063789

A_51_P333441

A_51_P465591

A_52_P181394

A_52_P675611

A_55_P2033425

A_55_P2112464

A_55_P2316783

A_55_P2729031

A_66_P106601

GE133418

GE1520589

GO:0001639

GO:0001640

GO:0002029

GO:0004930

GO:0005515

GO:0005737

GO:0005886

GO:0006355

GO:0007186

GO:0007196

GO:0007206

GO:0007216

GO:0007268

GO:0007611

GO:0007612

GO:0007626

GO:0008066

GO:0016020

GO:0023052

GO:0030296

GO:0030425

GO:0031687

GO:0034330

GO:0042802

GO:0043005

GO:0043025

GO:0043197

GO:0043198

GO:0043410

GO:0045202

GO:0045211

GO:0048169

GO:0048170

GO:0050804

GO:0050808

GO:0050850

GO:0050877

GO:0050890

GO:0051966

GO:0060078

GO:0060089

GO:0097449

GO:0098685

GO:0098772

GO:0098839

GO:0098978

GO:0099530

GO:0099553

GO:0099566

GO:0099583

GO:1904646

GO:1990782

ILMN_1226905

ILMN_1232417

ILMN_1242344

ILMN_1242601

ILMN_1243437

ILMN_1248753

ILMN_2540719

ILMN_2540934

mMC022452

mMC023915

Participates

as a member of

GRM1,GRM5 [plasma membrane] (Mus musculus)

Inferred From

GRM5 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001137306.1, XP_011239945.1

ENSEMBL

ENSMUST00000155358, ENSMUSP00000114927, ENSMUSG00000049583

ZINC - Substances

GRM5_MOUSE

ZINC target

Q3UVX5

PRO

Q3UVX5

GlyGen

Q3UVX5

MGI

1351342

ZINC - Predictions - Purchasable

GRM5_MOUSE

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.544	2
UniProt:P16056	7	phospho-p-Y1349,Y1356-MET [plasma membrane] (R-MMU-6807032) phospho-p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-MMU-6807014) phospho-MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-MMU-8875181) phospho-MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-MMU-8875180) phospho-p-Y1003,4Y-MET [plasma membrane] (R-MMU-8874689) MET [plasma membrane] (R-MMU-419603) phospho-p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-MMU-6806973)	0.518	3

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