Reactome | Nrp1 [plasma membrane]

Nrp1 [plasma membrane]

Stable Identifier

R-MMU-421085

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

Neuropilin-1, NRP1_MOUSE

Locations in the PathwayBrowser

Expand all

Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - L1CAM interactions (Mus musculus)
      - Signal transduction by L1 (Mus musculus)
        
        L1 binds NRP1 (Mus musculus)
        
        L1:NRP1 [plasma membrane] (Mus musculus)
        
        Nrp1 [plasma membrane] (Mus musculus)
        
        Nrp1 [plasma membrane] (Mus musculus)
    - Semaphorin interactions (Mus musculus)
      - CRMPs in Sema3A signaling (Mus musculus)
        
        Phosphorylation of CRMPs by Cdk5 (Mus musculus)
        
        Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Mus musculus)
        
        NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Mus musculus)
        
        Nrp1 [plasma membrane] (Mus musculus)
        
        Sema3A:Nrp-1:PlexinA:Fyn:pCdk5 [plasma membrane] (Mus musculus)
        
        NRP1:PlexinA1-4:FYN:pCdk5:p53 [plasma membrane] (Mus musculus)
        
        Nrp1 [plasma membrane] (Mus musculus)
        
        Phosphorylation of CRMPs by GSK3beta (Mus musculus)
        
        Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Mus musculus)
        
        NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Mus musculus)
        
        Nrp1 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylation of CRMPs by Fes (Mus musculus)
        
        Sema3A:NP-1:Plexin-A:Fes:CRMP [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Mus musculus)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Mus musculus)
        
        Nrp1 [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Mus musculus)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Mus musculus)
        
        Nrp1 [plasma membrane] (Mus musculus)
      - SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (Mus musculus)
        
        Sema3A binds Nrp-1 bound to PlexinA (Mus musculus)
        
        NRP1:PlexinA1-4:FARP2:FYN [plasma membrane] (Mus musculus)
        
        Nrp1 [plasma membrane] (Mus musculus)
        
        Sema3A:Nrp-1:Plexin A:Fyn [plasma membrane] (Mus musculus)
        
        NRP1:Plexin-A1-4:FYN [plasma membrane] (Mus musculus)
        
        Nrp1 [plasma membrane] (Mus musculus)
      - Sema3A PAK dependent Axon repulsion (Mus musculus)
        
        Activation of PAK by Rac1 (Mus musculus)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Mus musculus)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Mus musculus)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Mus musculus)
        
        Nrp1 [plasma membrane] (Mus musculus)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Mus musculus)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Mus musculus)
        
        Nrp1 [plasma membrane] (Mus musculus)
        
        Autophosphorylation of PAK (Mus musculus)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Mus musculus)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Mus musculus)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Mus musculus)
        
        Nrp1 [plasma membrane] (Mus musculus)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Mus musculus)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Mus musculus)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Mus musculus)
        
        Nrp1 [plasma membrane] (Mus musculus)
        
        Phosphorylation of LIMK-1 by PAK (Mus musculus)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Mus musculus)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Mus musculus)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Mus musculus)
        
        Nrp1 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P97333 Nrp1

Gene Names

Nrp1, Nrp

Chain

signal peptide:1-21, chain:22-923

Reference Genes

BioGPS Gene:18186 Nrp1

KEGG:mmu:18186 Nrp1

Monarch:18186 Nrp1

NCBI Gene:18186 Nrp1

UCSC:P97333 Nrp1

Reference Transcript

Other Identifiers

10576639

1418084_at

1457198_at

17506991

18186

4312235

4337987

4340007

4419212

4466366

4480601

4488041

4516242

4517575

4519241

4590289

4611421

4623021

4639821

4732211

4793578

4845484

4893651

4895230

4904235

4924232

5036849

5126881

5181338

5187845

5238097

5242959

5299697

5362113

5384551

5385765

5392424

5464544

5501472

5617212

95016_at

A_51_P469285

A_52_P371237

A_55_P2734297

A_55_P2738087

A_55_P2830615

A_65_P18472

D50086_s_at

GE34128

GO:0001525

GO:0001569

GO:0001570

GO:0001755

GO:0001764

GO:0002040

GO:0002042

GO:0003148

GO:0003824

GO:0005021

GO:0005096

GO:0005515

GO:0005737

GO:0005739

GO:0005768

GO:0005769

GO:0005829

GO:0005883

GO:0005886

GO:0005925

GO:0006930

GO:0007229

GO:0007399

GO:0007411

GO:0007413

GO:0007507

GO:0008045

GO:0008201

GO:0009611

GO:0009986

GO:0010595

GO:0010641

GO:0016020

GO:0016358

GO:0016740

GO:0017154

GO:0019838

GO:0019901

GO:0021612

GO:0021636

GO:0021637

GO:0021649

GO:0021785

GO:0021828

GO:0030154

GO:0030424

GO:0030426

GO:0030517

GO:0030947

GO:0031290

GO:0031410

GO:0031966

GO:0032489

GO:0035729

GO:0035767

GO:0035924

GO:0036486

GO:0038084

GO:0038085

GO:0038189

GO:0038190

GO:0042060

GO:0042327

GO:0043005

GO:0043025

GO:0043226

GO:0043524

GO:0043534

GO:0043542

GO:0045211

GO:0045766

GO:0046718

GO:0046872

GO:0048008

GO:0048010

GO:0048012

GO:0048485

GO:0048666

GO:0048675

GO:0048841

GO:0048842

GO:0048843

GO:0048844

GO:0048846

GO:0048856

GO:0048870

GO:0050731

GO:0050918

GO:0051491

GO:0051496

GO:0051894

GO:0060089

GO:0060385

GO:0060666

GO:0060978

GO:0060980

GO:0060982

GO:0061298

GO:0061299

GO:0061441

GO:0061549

GO:0061551

GO:0070374

GO:0071526

GO:0071673

GO:0071679

GO:0090050

GO:0097374

GO:0097443

GO:0097475

GO:0097490

GO:0097491

GO:0098772

GO:0098978

GO:0099173

GO:0120035

GO:0140096

GO:0150018

GO:0150020

GO:1900026

GO:1901166

GO:1902946

GO:1903375

GO:1904754

GO:1904835

GO:1905040

GO:2001237

ILMN_1237197

ILMN_1247094

ILMN_2669912

Msa.10100.0_s_at

mMC020762

mMR001211

Participates

as an input of

as a component of

Inferred From

NRP1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_006530829.1, NP_032763.2

ENSEMBL

ENSMUSG00000025810, ENSMUST00000026917, ENSMUSP00000026917

PRO

P97333

MGI

106206

PDB

7M0R, 4GZA, 4GZ9

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Z0G0	1	Gipc1 [cytoplasm] (R-MMU-9839329)	0.589	2
UniProt:Q9Z254	1	Gipc1 [cytoplasm] (R-RNO-9839329)	0.581	3
UniProt:O08665 Sema3a	2	Sema3a [extracellular region] (R-MMU-198235) Sema3a [extracellular region] (R-MMU-421091)	0.558	3
UniProt:P70207 Plxna2	2	Plexin-A2 [plasma membrane] (R-MMU-2045918) phospho-Plxna2 [plasma membrane] (R-MMU-419607)	0.558	3
UniProt:P70206 Plxna1	4	pPlexin-A1 [plasma membrane] (R-MMU-421082) Plxna1 [plasma membrane] (R-MMU-421079) phospho-Plxna1 [plasma membrane] (R-MMU-419614) Plxna1 [plasma membrane] (R-MMU-396932)	0.558	4
UniProt:P08648 ITGA5	3	ITGA5 [plasma membrane] (R-HSA-9857636) p-S-ITGA5 [plasma membrane] (R-HSA-9857662) ITGA5(42-894) [plasma membrane] (R-HSA-202735)	0.544	3
UniProt:Q61140 Bcar1	6	Bcar1 [cytosol] (R-MMU-201625) phospho-Bcar1 [cytosol] (R-MMU-8848723) phospho-Bcar1 [cytosol] (R-MMU-5218739) p130Cas [cytosol] (R-MMU-5218743) p-12Y-P130Cas [cytosol] (R-MMU-5218727) phospho-Bcar1 [cytosol] (R-MMU-372645)	0.463	2

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