Plexin-A binds to neuropilin-1

Stable Identifier
R-MMU-421140
Type
Reaction [binding]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Plexin-A binds to neuropilin-1
The best characterized receptors for mediating semaphorin signaling are members of the neuropilin and plexin families of transmembrane proteins. Neuropilins form complexes with Plexin-A which in turn can act as a signaling moiety. Also, when complexed with neuropilin-1, plexin-A1 can associate directly with the FERM domain containing guanine nucleotide exchange factor (GEF) FARP2. FARP2 exerts GEF activity for Rac but not Cdc42 and Rho.
Literature References
PubMed ID Title Journal Year
16286926 FARP2 triggers signals for Sema3A-mediated axonal repulsion

Zhang, H, Yoshida, J, Toyofuku, T, Kumanogoh, A, Sugimoto, T, Kikutani, H, Hori, M

Nat Neurosci 2005
10520994 Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors

Murakami, Y, Nakamura, F, Strittmatter, SM, Kalb, RG, Fujisawa, H, Wang, LH, Takahashi, T, Fournier, A

Cell 1999
Participants
Orthologous Events
Authored
Reviewed
Created
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