Activation of Rac1 by FARP2

Stable Identifier
R-MMU-421147
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Activation of Rac1 by FARP2

Sema3A-mediated dissociation of FARP2 from Plexin-A is followed by activation of Rac1 by the GEF activity of released FARP2.
FARP2 is critical for Sema3A-mediated axonal repulsion through two independent downstream signaling pathways. Sema3A mediated disassociation of FARP2 from Plexin-A is followed by activation of Rac by GEF activity of released FARP2, binding of Rnd1 to plexin-A and down regulation of R-Ras by GAP activity of plexin-A.

Literature References
PubMed ID Title Journal Year
17607942 The CRMP family of proteins and their role in Sema3A signaling

Schmidt, EF, Strittmatter, SM

Adv Exp Med Biol 2007
16286926 FARP2 triggers signals for Sema3A-mediated axonal repulsion

Toyofuku, T, Yoshida, J, Sugimoto, T, Zhang, H, Kumanogoh, A, Hori, M, Kikutani, H

Nat Neurosci 2005
Participants
Catalyst Activity
Catalyst Activity
Title
Rac guanyl-nucleotide exchange factor activity of FARP2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created