Activation of Gq by Muscarinic Acetylcholine Receptor M3

Stable Identifier
R-MMU-426547
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane, cytosol
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activation of Gq by Muscarinic Acetylcholine Receptor M3

The binding of acetylcholine to the Muscarinic Acetylcholine Receptor M3 activates the heterotrimeric G protein, Gq, associated with the M3 receptor. Activation occurs through protein-protein interaction and results in the alpha subunit of Gq exchanging GDP for GTP (i.e releasing GDP and binding GTP). The 3 subunits of the G protein then dissociate into an alpha:GTP complex and a beta:gamma complex.

Literature References
PubMed ID Title Journal Year
17919190 Role of the M3 muscarinic acetylcholine receptor in beta-cell function and glucose homeostasis

Gautam, D, Han, SJ, Duttaroy, A, Mears, D, Hamdan, FF, Li, JH, Cui, Y, Jeon, J, Wess, J

Diabetes Obes Metab 2007
16753580 A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo

Gautam, D, Han, SJ, Hamdan, FF, Jeon, J, Li, B, Li, JH, Cui, Y, Mears, D, Lu, H, Deng, C, Heard, T, Wess, J

Cell Metab 2006
Participants
Input
Output
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of Muscarinic Receptor M3: Acetylcholine Complex [plasma membrane]
Physical Entity
Muscarinic Receptor M3: Acetylcholine Complex [plasma membrane]
Activity
guanyl-nucleotide exchange factor activity (0005085)
Orthologous Events
Muscarinic Acetylcholine Receptor M3 activates Gq (Homo sapiens)
Authored
May, B  (2009-06-08)
Reviewed
May, B  (2010-05-14)
Created
May, B  (2009-06-16)