The binding of acetylcholine to the Muscarinic Acetylcholine Receptor M3 activates the heterotrimeric G protein, Gq, associated with the M3 receptor. Activation occurs through protein-protein interaction and results in the alpha subunit of Gq exchanging GDP for GTP (i.e releasing GDP and binding GTP). The 3 subunits of the G protein then dissociate into an alpha:GTP complex and a beta:gamma complex.
Gautam, D, Han, SJ, Duttaroy, A, Mears, D, Hamdan, FF, Li, JH, Cui, Y, Jeon, J, Wess, J
Gautam, D, Han, SJ, Hamdan, FF, Jeon, J, Li, B, Li, JH, Cui, Y, Mears, D, Lu, H, Deng, C, Heard, T, Wess, J
guanyl-nucleotide exchange factor activity of Muscarinic Receptor M3: Acetylcholine Complex [plasma membrane]
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