Thrombin-activated PAR binds G-protein G12/13

Stable Identifier
R-MMU-427858
Type
Reaction
Species
Mus musculus
Compartment
Summation

Thrombin receptors activate G-proteins in the G12/13 family. Gq knockout mice exhibit defective platelet activation, but retain shape change responses to thrombin, mediated by G12/13.

Literature References
PubMed ID Title Journal Year
14528298 G13 is an essential mediator of platelet activation in hemostasis and thrombosis

Moers, A, Nieswandt, B, Massberg, S, Wettschureck, N, Grüner, S, Konrad, I, Schulte, V, Aktas, B, Gratacap, MP, Simon, MI, Gawaz, M, Offermanns, S

Nat Med 2003
Participants
Orthologous Events
Authored
Reviewed