Reactome | Arhgef7 [cytosol]

Arhgef7 [cytosol]

Stable Identifier

R-MMU-430346

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

ARHGEF7, Q9ES28

Locations in the PathwayBrowser

Expand all

Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - EPH-Ephrin signaling (Mus musculus)
      - Ephrin signaling (Mus musculus)
        
        GIT1 binds bPIX (Mus musculus)
        
        Arhgef7 [cytosol] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
        
        Arhgef7 [cytosol] (Mus musculus)
        
        PAK binds RAC and bPIX (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
        
        Arhgef7 [cytosol] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
        
        Arhgef7 [cytosol] (Mus musculus)
        
        PAKs autophosphorylate (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
        
        Arhgef7 [cytosol] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
        
        Arhgef7 [cytosol] (Mus musculus)
        
        bPIX exchanges GTP for GDP on RAC, activating it (Mus musculus)
        
        Arhgef7 [cytosol] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
        
        Arhgef7 [cytosol] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
        
        Arhgef7 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9ES28

Gene Names

Arhgef7

Reference Genes

BioGPS Gene:54126 Arhgef7

ENSEMBL:ENSMUSG00000031511

ENSEMBL:ENSMUSG00000031511.17 Arhgef7

KEGG Gene (Mus musculus):54126 Arhgef7

Monarch:54126 Arhgef7

NCBI Gene:54126 Arhgef7

UCSC:Q9ES28 Arhgef7

Reference Transcript

Other Identifiers

10570144

106830_at

1424482_at

1449066_a_at

17499038

4448921

4467246

4534169

4566861

4577866

4610085

4611097

4623009

4723901

4725344

4754958

4771713

4813407

4819309

4854094

4891988

4942138

4967403

4989012

5001159

5018297

5026101

5045780

5056207

5071714

5121291

5142567

5143477

5149553

5178745

5273611

5274108

5314464

54126

5467762

5500072

5514479

5516613

5613813

98434_at

A_52_P26357

A_55_P1976242

GE41868

GE42759

GO:0000322

GO:0001726

GO:0002244

GO:0005085

GO:0005515

GO:0005737

GO:0005773

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0005938

GO:0007010

GO:0007030

GO:0007264

GO:0007266

GO:0007399

GO:0008092

GO:0012501

GO:0019901

GO:0023052

GO:0030027

GO:0030032

GO:0030154

GO:0030426

GO:0031267

GO:0032991

GO:0034330

GO:0035556

GO:0042995

GO:0043005

GO:0043015

GO:0043025

GO:0043065

GO:0043226

GO:0043547

GO:0043615

GO:0048856

GO:0048870

GO:0060124

GO:0065003

GO:0070161

GO:0097431

GO:0098772

GO:0098794

GO:0098974

GO:0098982

GO:0099140

GO:1905833

ILMN_1213960

ILMN_2486818

U96634_s_at

mMC024606

Participates

as a candidate of

as an input of

GIT1 binds bPIX (Mus musculus)

as a component of

as a member of

GEFs [cytosol] (Mus musculus)

Inferred From

ARHGEF7 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_006508907.2, XP_006508904.2, NP_059098.2, NP_001106989.1, XP_006508906.2, NP_001106990.1

Ensembl

ENSMUSP00000096538, ENSMUSP00000106534, ENSMUST00000110909, ENSMUSG00000031511, ENSMUST00000098938

PRO

Q9ES28

MGI

1860493

PDB

2ESW, 6JMT

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HBI1 PARVB	1	PARVB [cytosol] (R-HSA-446016)	0.619	10
UniProt:Q68FF6 Git1	4	p-Y392-Git1 [cytosol] (R-MMU-3928429) Git1 [cytosol] (R-MMU-3928400) phospho-Git1 [cytosol] (R-MMU-3928463) Git1 [cytosol] (R-MMU-430326)	0.564	2
UniProt:Q9QX74-4 SHANK2			0.558	3
UniProt:Q14161 GIT2	1	GIT2 [cytosol] (R-HSA-446034)	0.499	2
UniProt:Q9Z272 Git1	3	phospho-Git1 [cytosol] (R-RNO-3928463) Git1 [cytosol] (R-RNO-9619771) Git1 [cytosol] (R-RNO-430326)	0.499	2
UniProt:P26433	1	SLC9A3 [plasma membrane] (R-RNO-425992)	0.462	2