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Vav1 [cytosol]
Stable Identifier
R-MMU-434625
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Proto-oncogene vav, VAV_MOUSE, Vav1
Locations in the PathwayBrowser
Expand all
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
GPVI-mediated activation cascade (Mus musculus)
VAV1 is a GEF for Rho/Rac family GTPases (Mus musculus)
PIP3:VAV1,2,3 [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
VAV family:PIP2 [plasma membrane] (Mus musculus)
VAV family [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
p-SLP-76 binds VAV (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
p-SLP-76:VAV [cytosol] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Costimulation by the CD28 family (Mus musculus)
CD28 co-stimulation (Mus musculus)
CD28 dependent Vav1 pathway (Mus musculus)
Activation of Vav1 (Mus musculus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Translocation of Vav1 to CD28 (Mus musculus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Mus musculus)
BTK binds BTK inhibitors (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
BTK:BTK inhibitors [plasma membrane] (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
IL3 stimulation induces Vav binding to Tec kinase (Mus musculus)
TEC:VAV1 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Regulation of signaling by CBL (Mus musculus)
CBL binds VAV (Mus musculus)
Vav1 [cytosol] (Mus musculus)
p(Y700,731,774)-CBL:VAV1 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated Ca+2 mobilization (Mus musculus)
Autophosphorylation of BTK/ITK (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Hydrolysis of PIP2 by PLCG (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Phosphorylation of TEC kinases by p-SYK (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
FCERI mediated MAPK activation (Mus musculus)
Phosphorylation and activation of VAV (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Recruitment of VAV to p-SLP-76 (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
Phosphorylation of VAV (Mus musculus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Recruitment of VAV1 to p-6Y-SYK (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
Cell death signalling via NRAGE, NRIF and NADE (Mus musculus)
NRAGE signals death through JNK (Mus musculus)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Mus musculus)
GEFs [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Signaling by Erythropoietin (Mus musculus)
Erythropoietin activates RAS (Mus musculus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Mus musculus)
GRB2-1:VAV1 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
GRB2-1:VAV1 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (12/13) signalling events (Mus musculus)
GEFs activate RhoA,B,C (Mus musculus)
GEFs [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by SCF-KIT (Mus musculus)
Phosphorylation and activation of VAV1 (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
Src kinases phosphorylate VAV (Mus musculus)
PIP3:VAV1,2,3 [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)
VAV family [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase cycle (Mus musculus)
RAC1 GTPase cycle (Mus musculus)
RAC1 GEFs activate RAC1 (Mus musculus)
RAC1 GEFs [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
RAC2 GTPase cycle (Mus musculus)
RAC2 GEFs activate RAC2 (Mus musculus)
RAC2 GEFs [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
RHOA GTPase cycle (Mus musculus)
RHOA GEFs activate RHOA (Mus musculus)
RHOA GEFs [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
RHOG GTPase cycle (Mus musculus)
RHOG GEFs activate RHOG (Mus musculus)
RHOG GEFs [cytosol] (Mus musculus)
Vav1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P27870 Vav1
Gene Names
Vav1, Vav
Chain
chain:1-845
Reference Genes
BioGPS Gene:22324 Vav1
ENSEMBL:ENSMUSG00000034116.18 Vav1
KEGG Gene (Mus musculus):22324 Vav1
Monarch:22324 Vav1
NCBI Gene:22324 Vav1
UCSC:P27870 Vav1
Reference Transcript
RefSeq:NM_011691.4 Vav1
Other Identifiers
10446253
1422932_a_at
17338982
22324
4333211
4368377
4404873
4480068
4516603
4565195
4689181
4713377
4728940
4768343
4788913
4789923
4878394
4896071
4916631
4987365
5005833
5095826
5121522
5202961
5203146
5239731
5273983
5432319
5468457
5520006
5529532
5535363
5616335
96511_s_at
97562_r_at
99799_at
A_52_P173726
A_55_P2036567
GE36263
GO:0001784
GO:0002376
GO:0005085
GO:0005515
GO:0005737
GO:0005829
GO:0005911
GO:0006909
GO:0006955
GO:0007155
GO:0007166
GO:0007186
GO:0007229
GO:0008361
GO:0016192
GO:0016477
GO:0023052
GO:0030154
GO:0030217
GO:0030593
GO:0035556
GO:0042110
GO:0045785
GO:0045954
GO:0046872
GO:0048856
GO:0048870
GO:0072593
GO:0098542
GO:0098772
GO:0140031
ILMN_1224077
Msa.2530.0_at
d83266_at
d83266_g_at
mMC000871
Participates
as a component of
Grb2-1:Vav1 [cytosol] (Mus musculus)
GRB2-1:VAV1 [cytosol] (Mus musculus)
Vav1:PIP2 [cytosol] (Mus musculus)
TEC:VAV1 [cytosol] (Mus musculus)
p(Y700,731,774)-CBL:VAV1 [cytosol] (Mus musculus)
PIP3:Vav1 [cytosol] (Mus musculus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Mus musculus)
p-Y513,Y482,Y391-Cd19:Vav1 [plasma membrane] (Mus musculus)
Cd19:Vav1 [plasma membrane] (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Mus musculus)
as a member of
RHOA GEFs [cytosol] (Mus musculus)
RAC2 GEFs [cytosol] (Mus musculus)
RAC1 GEFs [cytosol] (Mus musculus)
RHOG GEFs [cytosol] (Mus musculus)
GEFs [cytosol] (Mus musculus)
VAV family [cytosol] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
as an input of
PIP2 inhibits Vav1 (Mus musculus)
Phosphorylation and activation of VAV1 (Mus musculus)
IL3 stimulation induces Vav binding to Tec kinase (Mus musculus)
CBL binds VAV (Mus musculus)
PIP3 stimulates Vav1 (Mus musculus)
Translocation of Vav1 to CD28 (Mus musculus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Mus musculus)
Other forms of this molecule
p-Y-Vav1 [cytosol]
phospho-Vav1 [plasma membrane]
phospho-Vav1 [cytosol]
Vav1 [plasma membrane]
Inferred From
VAV1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_035821.3
Ensembl
ENSMUSP00000005889
,
ENSMUST00000005889
,
ENSMUSG00000034116
PRO
P27870
MGI
98923
PDB
2KBT
,
1K1Z
,
1GCP
,
1GCQ
,
2VRW
,
1F5X
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61979
2
Hnrnpk [nucleoplasm]
(R-MMU-4570532)
Hnrnpk [nucleoplasm]
(R-MMU-71945)
0.593
3
UniProt:P19878 NCF2
2
p-T233-NCF2 [phagolysosome]
(R-HSA-1996211)
NCF2 [cytosol]
(R-HSA-1222600)
0.524
4
UniProt:Q3U1F9
2
Pag1 [plasma membrane]
(R-MMU-180500)
phospho-Pag1 [plasma membrane]
(R-MMU-180494)
0.499
3
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