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Vav1 [cytosol]
Stable Identifier
R-MMU-434625
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Proto-oncogene vav, VAV_MOUSE, Vav1
Locations in the PathwayBrowser for interactor UniProt:P19878 NCF2
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Regulation of T cell activation by CD28 family (Mus musculus)
Co-stimulation by CD28 (Mus musculus)
CD28 dependent Vav1 pathway (Mus musculus)
Translocation of Vav1 to CD28 (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Mus musculus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
IL3 stimulation induces Vav binding to Tec kinase (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Regulation of signaling by CBL (Mus musculus)
CBL binds VAV (Mus musculus)
Vav1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by SCF-KIT (Mus musculus)
Phosphorylation and activation of VAV1 (Mus musculus)
Vav1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P27870 Vav1
Gene Names
Vav1, Vav
Chain
chain:1-845
Reference Genes
BioGPS Gene:22324 Vav1
KEGG:mmu:22324 Vav1
Monarch:22324 Vav1
NCBI Gene:22324 Vav1
UCSC:P27870 Vav1
Reference Transcript
RefSeq:NM_011691.4 Vav1
Other Identifiers
10446253
134150_at
1422932_a_at
1440300_at
17338982
22324
4333211
4368377
4404873
4480068
4516603
4547863
4565195
4603267
4689181
4713377
4728940
4768343
4788913
4789923
4862733
4878394
4896071
4916631
4987365
5005833
5095826
5121522
5202961
5203146
5231214
5239731
5273983
5432319
5468457
5520006
5529532
5535363
5616335
96511_s_at
97562_r_at
99799_at
A_51_P154780
A_52_P173726
A_55_P2036567
GE36263
GO:0001784
GO:0002376
GO:0005085
GO:0005515
GO:0005737
GO:0005829
GO:0005911
GO:0006909
GO:0006955
GO:0007165
GO:0007166
GO:0007186
GO:0007229
GO:0008361
GO:0016192
GO:0016477
GO:0030101
GO:0030154
GO:0030217
GO:0030593
GO:0031295
GO:0035556
GO:0042110
GO:0042267
GO:0045785
GO:0045954
GO:0046872
GO:0048870
GO:0072593
GO:0098542
GO:0098772
GO:0140031
ILMN_1224077
Msa.2530.0_at
d83266_at
d83266_g_at
mMC000871
Participates
as a component of
Grb2-1:Vav1 [cytosol] (Mus musculus)
Vav1:PIP2 [cytosol] (Mus musculus)
TEC:VAV1 [cytosol] (Mus musculus)
p(Y700,731,774)-CBL:VAV1 [cytosol] (Mus musculus)
PIP3:Vav1 [cytosol] (Mus musculus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Mus musculus)
p-Y513,Y482,Y391-Cd19:Vav1 [plasma membrane] (Mus musculus)
Cd19:Vav1 [plasma membrane] (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Mus musculus)
as a member of
RHOA GEFs [cytosol] (Mus musculus)
RAC2 GEFs [cytosol] (Mus musculus)
RAC1 GEFs [cytosol] (Mus musculus)
RHOG GEFs [cytosol] (Mus musculus)
GEFs [cytosol] (Mus musculus)
VAV family [cytosol] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
as an input of
PIP2 inhibits Vav1 (Mus musculus)
IL3 stimulation induces Vav binding to Tec kinase (Mus musculus)
CBL binds VAV (Mus musculus)
PIP3 stimulates Vav1 (Mus musculus)
Translocation of Vav1 to CD28 (Mus musculus)
Phosphorylation and activation of VAV1 (Mus musculus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Mus musculus)
Other forms of this molecule
p-Y-Vav1 [cytosol]
phospho-Vav1 [plasma membrane]
phospho-Vav1 [cytosol]
Vav1 [plasma membrane]
Inferred From
VAV1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_035821.3
ENSEMBL
ENSMUST00000005889
,
ENSMUSP00000005889
PRO
P27870
MGI
98923
PDB
2KBT
,
1GCP
,
1GCQ
,
1K1Z
,
1F5X
,
2VRW
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61979
2
Hnrnpk [nucleoplasm]
(R-MMU-4570532)
Hnrnpk [nucleoplasm]
(R-MMU-71945)
0.593
3
UniProt:P19878 NCF2
2
NCF2 [cytosol]
(R-HSA-1222600)
p-T233-NCF2 [phagolysosome]
(R-HSA-1996211)
0.524
4
UniProt:Q3U1F9
2
Pag1 [plasma membrane]
(R-MMU-180500)
phospho-Pag1 [plasma membrane]
(R-MMU-180494)
0.499
3
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