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VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane]
Stable Identifier
R-MMU-4420164
Type
Complex
Species
Mus musculus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
CRK binds BCAR1 and or PXN (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
DOCK180:ELMO binds CRK (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
HSP90AA1 binds p-6Y-VEGFR2 (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
PTK2 autophosphorylates (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
PXN binds p-6Y,S732-PTK2 (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
SRC-1 binds p-Y397-PTK2 (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
SRC-1 phosphorylates PTK2-beta (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
SRC-1 phosphorylates SHB (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
SRC-1 phosphorylates p-Y397-PTK2 (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
Src kinases phosphorylate VAV (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
phospho-Shb [cytosol]
(Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane]
(Mus musculus)
Participates
as a component of
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2 [plasma membrane] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
as an input of
PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Mus musculus)
as an output of
SRC-1 phosphorylates SHB (Mus musculus)
Inferred From
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane]
(Homo sapiens)
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