Activation of WASP and N-WASP by CDC42

Stable Identifier
R-MMU-442572
Type
Reaction
Species
Mus musculus
Compartment
Summation

The activation of WASP and N-WASP (WASL) by CDC42:GTP was demonstrated by mouse system-based experiments (Symons et al. 1996, Kolluri et al. 1996, Rohatgi et al. 1999, Park and Cox 2009)

Literature References
PubMed ID Title Journal Year
8625410 Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

Symons, M, Derry, JM, Karlak, B, Jiang, S, Lemahieu, V, McCormick, F, Francke, U, Abo, A

Cell 1996
10219243 The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

Rohatgi, R, Ma, L, Miki, H, Lopez, M, Kirchhausen, Tomas, Takenawa, T, Kirschner, MW

Cell 1999
19741094 Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP

Park, H, Cox, D

Mol Biol Cell 2009
8643625 Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42

Kolluri, R, Tolias, KF, Carpenter, CL, Rosen, FS, Kirchhausen, Tomas

Proc Natl Acad Sci U S A 1996
Participants
Orthologous Events
Authored
Reviewed