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Grb2 [cytosol]
Stable Identifier
R-MMU-443287
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
External Reference Information
External Reference
UniProt:Q60631 Grb2
Gene Names
Grb2
Chain
chain:1-217
Reference Genes
BioGPS Gene:14784 Grb2
ENSEMBL:ENSMUSG00000059923.14 Grb2
KEGG Gene (Mus musculus):14784 Grb2
Monarch:14784 Grb2
NCBI Gene:14784 Grb2
UCSC:Q60631 Grb2
Reference Transcript
RefSeq:NM_001313936.1 Grb2
RefSeq:NM_001313937.1 Grb2
RefSeq:NM_008163.4 Grb2
Other Identifiers
101034_at
10392990
1418508_a_at
1449111_a_at
14784
17272004
4311802
4387111
4420339
4425001
4599844
4621585
4780811
4814468
4983599
5066515
5109277
5119057
5148685
5153093
5236475
5312349
5312784
5463859
5553561
A_55_P2123727
GE34513
GO:0001784
GO:0002376
GO:0005068
GO:0005091
GO:0005154
GO:0005168
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005768
GO:0005794
GO:0005829
GO:0005886
GO:0005911
GO:0005938
GO:0007010
GO:0007165
GO:0007173
GO:0007265
GO:0008180
GO:0008286
GO:0008543
GO:0012506
GO:0014044
GO:0016020
GO:0016192
GO:0017124
GO:0019899
GO:0019901
GO:0019903
GO:0019904
GO:0023052
GO:0030036
GO:0030154
GO:0030674
GO:0030838
GO:0031410
GO:0031623
GO:0032991
GO:0035987
GO:0038133
GO:0042552
GO:0042770
GO:0042802
GO:0043226
GO:0043408
GO:0043560
GO:0044877
GO:0046875
GO:0048009
GO:0048646
GO:0048856
GO:0050853
GO:0051219
GO:0060090
GO:0060670
GO:0065003
GO:0070436
GO:0071479
GO:0098772
GO:2000379
ILMN_1222450
ILMN_2995537
mMC014789
u07617_s_at
Participates
as a component of
Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:p-Y-Shc1:p-Y-Gab2:Grb2:p-Y546,Y584-Ptpn11 [plasma membrane] (Mus musculus)
Shp2:Grb2 [cytosol] (Mus musculus)
Il15:Il15ra:p-Y-Il2rb:p-Y-Il2rg:p-Y-Jak1:p-Y-Jak3:p-Y-Shc:Grb2 [plasma membrane] (Mus musculus)
Grb2:p-3Y-Gab2 [cytosol] (Mus musculus)
Grb2:Gab2 [cytosol] (Mus musculus)
Active Flt3:Grb2 [plasma membrane] (Mus musculus)
as an input of
Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds and phosphorylates Shc1, Grb2, Gab2, and Ptpn11 (Mus musculus)
Shp2 can recruit Grb2 (Mus musculus)
Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1 binds Grb2 (Mus musculus)
Recruitment of Gab2 to PM and FCERI by binding to Grb2 (Mus musculus)
Active Flt3 dimer binds Grb2 (Mus musculus)
Cross References
RefSeq
NP_032189.1
,
NP_001300865.1
,
NP_001300866.1
Ensembl
ENSMUST00000106497
,
ENSMUSP00000021090
,
ENSMUST00000106499
,
ENSMUST00000021090
,
ENSMUSP00000102106
,
ENSMUSP00000102108
,
ENSMUSG00000059923
ZINC target
Q60631
PRO
Q60631
MGI
95805
ZINC - Predictions - Purchasable
GRB2_MOUSE
PDB
3GBQ
,
1GBQ
,
4GBQ
,
1GBR
,
2GBQ
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P98083 Shc1
2
p-Y-Shc1 [cytosol]
(R-MMU-8983175)
Shc1 [cytosol]
(R-MMU-1248757)
0.899
8
UniProt:Q9QYY0 Gab1
5
phospho-Gab1 [cytosol]
(R-MMU-8855306)
Gab1 [cytosol]
(R-MMU-9031464)
phospho-Gab1 [cytosol]
(R-MMU-180496)
phospho-Gab1 [cytosol]
(R-MMU-180344)
Gab1 [cytosol]
(R-MMU-179795)
0.791
9
UniProt:Q62245 Sos1
4
phospho-Sos1 [cytosol]
(R-MMU-109821)
Sos1 [cytosol]
(R-MMU-443318)
Sos1 [plasma membrane]
(R-MMU-983559)
Sos1 [cytosol]
(R-MMU-64847)
0.757
7
UniProt:Q02384
1
Sos2 [cytosol]
(R-MMU-167221)
0.678
5
UniProt:O54957
4
phospho-Lat [plasma membrane]
(R-MMU-434829)
Lat [plasma membrane]
(R-MMU-202322)
phospho-Lat [plasma membrane]
(R-MMU-202364)
phospho-Lat [plasma membrane]
(R-MMU-2396597)
0.669
5
UniProt:P18052
1
PTPRA [plasma membrane]
(R-MMU-388755)
0.656
4
UniProt:P22682 Cbl
8
Cbl [cytosol]
(R-MMU-9680636)
p-Y-Cbl [cytosol]
(R-MMU-9680645)
phospho-p-Y-CBL [cytosol]
(R-MMU-8875457)
phospho-p-Y371-CBL [cytosol]
(R-MMU-182940)
phospho-p-Y371-CBL [plasma membrane]
(R-MMU-182923)
phospho-PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
(R-MMU-8848826)
phospho-p-Y700,Y731,Y774-CBL [cytosol]
(R-MMU-912656)
CBL [cytosol]
(R-MMU-112199)
0.643
7
UniProt:P35329
3
NAc-CD22 [plasma membrane]
(R-MMU-5690736)
CD22 [plasma membrane]
(R-MMU-197703)
phospho-p-Y762,807,822-CD22 [plasma membrane]
(R-MMU-5690726)
0.623
4
UniProt:Q61234 SNTA1
0.618
3
UniProt:P04925 Prnp
2
PRNP [cytosol]
(R-MMU-9617597)
Major prion protein [plasma membrane]
(R-MMU-420340)
0.618
7
UniProt:P35235 Ptpn11
5
p-Y546,Y584-Shp2 [cytosol]
(R-MMU-443116)
Ptpn11 [cytosol]
(R-MMU-210002)
PTPN11 [nucleoplasm]
(R-MMU-8937745)
PTPN11 [cytosol]
(R-MMU-162563)
phospho-p-Y542,Y580-PTPN11 [cytosol]
(R-MMU-162573)
0.59
3
UniProt:P98078
3
Dab2 [cytosol]
(R-MMU-8862456)
Dab2 [lysosomal membrane]
(R-MMU-2980807)
Dab2 [plasma membrane]
(R-MMU-2980808)
0.576
4
UniProt:Q60749
3
Khdrbs1 [nucleoplasm]
(R-MMU-8848941)
phospho-Khdrbs1 [cytosol]
(R-MMU-8848995)
phospho-Khdrbs1 [nucleoplasm]
(R-MMU-8848970)
0.573
2
UniProt:Q61824 Adam12
2
ADAM 12 metalloprotease [plasma membrane]
(R-MMU-179841)
ADAM12 [plasma membrane]
(R-MMU-179792)
0.571
3
UniProt:Q62077 Plcg1
10
p-Y-Plcg1 [cytosol]
(R-MMU-9029083)
Plcg1 [cytosol]
(R-MMU-9638030)
p-4Y-Plcg1 [plasma membrane]
(R-MMU-9030452)
P-Plcg1 [cytosol]
(R-MMU-1251936)
Plcg1 [plasma membrane]
(R-MMU-1251925)
phospho-p-Y771,Y783-PLCG1 [plasma membrane]
(R-MMU-1169084)
phospho-p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-MMU-202357)
PLCG1 [cytosol]
(R-MMU-202320)
PLCG1 [plasma membrane]
(R-MMU-167682)
phospho-p-4Y-PLCG1 [plasma membrane]
(R-MMU-167679)
0.564
2
UniProt:Q02858 Tek
4
Phosphorylated_Tie2 [plasma membrane]
(R-MMU-211116)
Tie2 [plasma membrane]
(R-MMU-211118)
TEK [plasma membrane]
(R-MMU-197755)
phospho-p-5Y,S1119-TEK [plasma membrane]
(R-MMU-204772)
0.548
3
UniProt:Q3TTA7
1
CBLB [cytosol]
(R-MMU-976009)
0.527
6
UniProt:Q8C180 Frs2
6
p-Y-Frs2 [cytosol]
(R-MMU-9031970)
Frs2 [cytosol]
(R-MMU-443125)
phospho-Frs2 [cytosol]
(R-MMU-190355)
phospho-Frs2 [plasma membrane]
(R-MMU-1270462)
Frs2 [plasma membrane]
(R-MMU-170963)
phospho-Frs2 [plasma membrane]
(R-MMU-170959)
0.527
5
UniProt:Q52KG5
1
KIF26A [cytosol]
(R-MMU-984675)
0.508
2
UniProt:P34152 Ptk2
2
p-Y428-FAK1 [cytosol]
(R-MMU-3928397)
Fak1 [cytosol]
(R-MMU-3928448)
0.508
2
UniProt:Q3U1F9
2
Pag1 [plasma membrane]
(R-MMU-180500)
phospho-Pag1 [plasma membrane]
(R-MMU-180494)
0.499
5
UniProt:Q9DD03 Rab13
4
GGC-Rab13 [cytoplasmic vesicle membrane]
(R-MMU-1445096)
GGC-RAB13 [cell junction]
(R-MMU-8876591)
GGC-RAB13 [cytosol]
(R-MMU-8873767)
RAB13 [cytosol]
(R-MMU-8873674)
0.463
2
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