Reactome | Numb [plasma membrane]

Numb [plasma membrane]

Stable Identifier

R-MMU-443595

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

NUMB, Q9QZS3

Locations in the PathwayBrowser

Expand all

Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - L1CAM interactions (Mus musculus)
      - Recycling pathway of L1 (Mus musculus)
        
        Interaction of NUMB with L1 (Mus musculus)
        
        CRMP-2:NUMB:alpha adaptin [plasma membrane] (Mus musculus)
        
        Numb [plasma membrane] (Mus musculus)
        
        L1:NUMB:CRMP-2:alpha-adaptin [clathrin-coated endocytic vesicle] (Mus musculus)
        
        CRMP-2:NUMB:alpha adaptin [plasma membrane] (Mus musculus)
        
        Numb [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9QZS3 Numb

Gene Names

Numb

Chain

chain:1-653

Reference Genes

BioGPS Gene:18222 Numb

ENSEMBL:ENSMUSG00000021224 Numb

KEGG Gene (Mus musculus):18222 Numb

Monarch:18222 Numb

NCBI Gene:18222 Numb

UCSC:Q9QZS3 Numb

Reference Transcript

Other Identifiers

10401382

1416891_at

1425368_a_at

17282435

18222

4350588

4613963

4625932

4963678

5088019

5100532

5112144

5115381

5191424

5202482

5214799

5222195

5250368

5476023

5523767

5581725

5600330

5616929

99955_at

A_30_P01018473

A_30_P01025103

A_30_P01029299

A_51_P325071

A_52_P26216

A_52_P517905

GE35834

GO:0000902

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005768

GO:0005769

GO:0005886

GO:0005905

GO:0006810

GO:0007275

GO:0007399

GO:0007405

GO:0007409

GO:0008013

GO:0008150

GO:0008283

GO:0014069

GO:0015031

GO:0016020

GO:0016192

GO:0016323

GO:0019897

GO:0021670

GO:0021849

GO:0022607

GO:0030136

GO:0030154

GO:0030335

GO:0030900

GO:0031410

GO:0034330

GO:0034332

GO:0040011

GO:0043226

GO:0045177

GO:0045294

GO:0045296

GO:0045664

GO:0048856

GO:0048870

GO:0050769

GO:0050775

GO:0051301

GO:0098978

GO:0099149

GO:0099150

GO:1903077

ILMN_2418524

ILMN_2477665

ILMN_2502972

ILMN_2619583

ILMN_2678576

ILMN_2727687

ILMN_2727692

ILMN_2878726

U70674_s_at

mMC010471

mMR027590

Participant Of

hasComponent

input

NUMB binds ITCH

Other forms of this molecule

Numb [plasma membrane]

Inferred From

NUMB [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_006515640.1, NP_035079.1, XP_011242314.1, XP_006515641.1, XP_006515639.1, NP_001258984.1, NP_001129547.1, NP_001258985.1

Ensembl

ENSMUSG00000021224, ENSMUST00000154043, ENSMUST00000021647, ENSMUSP00000113591, ENSMUSP00000119303, ENSMUST00000129335, ENSMUSP00000021647, ENSMUST00000117217, ENSMUSP00000117899

PRO

Q9QZS3

MGI

107423

PDB

1WJ1, 5YQG

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05106 ITGB3	3	ITGB3(27-?) [platelet alpha granule membrane] (R-HSA-114512) p-T779-ITGB3 [plasma membrane] (R-HSA-432107) ITGB3 [plasma membrane] (R-HSA-57600)	0.544	2
UniProt:P12023	9	App [extracellular region] (R-MMU-976740) App [extracellular region] (R-MMU-879340) App [endoplasmic reticulum lumen] (R-MMU-8956696) phospho-App [endoplasmic reticulum lumen] (R-MMU-8957012) App [platelet alpha granule lumen] (R-MMU-139835) App [extracellular region] (R-MMU-49335) App [endosome lumen] (R-MMU-5229077) App [cytosol] (R-MMU-9617603) App [trans-Golgi network membrane] (R-MMU-5229136)	0.524	2