CHL1 interacts with contactin-6

Stable Identifier
R-MMU-443777
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CHL1 interacts with contactin-6
Close homolog of L1 (CHL1), associates with Contactin-6/NB-3, a member of the F3/contactin family of neural recognition molecules, and enhances its cell surface expression. CHL1 and NB3 may engage in a cis-interaction and form a coreceptor/adhesion complex on the neuronal surface.
CHL1/NB3 clustering activates protein tyrosine phosphatase alpha (PTP alpha), which dephosphorylates and activates Fyn. Both PTP alpha and Fyn are required for proper apical dendrite orientation of deep layer pyramidal neurons.
Literature References
PubMed ID Title Journal Year
18046458 Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha

Ye, H, Tan, YL, Pallen, CJ, Ponniah, S, Xiao, ZC, Watanabe, K, Schachner, M, Takeda, Y, Wang, SQ

EMBO J 2008
Participants
Input
Output
Orthologous Events
CHL1 interacts with contactin-6 (Homo sapiens)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-12)
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