Reactome | Gpr120 [plasma membrane]

Gpr120 [plasma membrane]

Stable Identifier

R-MMU-444173

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

G-protein coupled receptor 120, GP120_MOUSE, Gpr120

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (q) signalling events (Mus musculus)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        Gpr120:Fatty acid [plasma membrane] (Mus musculus)
        
        Gpr120 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        Gpr120:Fatty acid [plasma membrane] (Mus musculus)
        
        Gpr120 [plasma membrane] (Mus musculus)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        Gpr120:Fatty acid [plasma membrane] (Mus musculus)
        
        Gpr120 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        Gpr120:Fatty acid [plasma membrane] (Mus musculus)
        
        Gpr120 [plasma membrane] (Mus musculus)
      - The Ligand:GPCR:Gq complex dissociates (Mus musculus)
        
        GPCRs that activate Gq/11 [plasma membrane] (Mus musculus)
        
        Gpr120 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        Gpr120:Fatty acid [plasma membrane] (Mus musculus)
        
        Gpr120 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q7TMA4 Ffar4

Gene Names

Ffar4, Gpr120, O3far1

Chain

chain:1-361

Reference Genes

BioGPS Gene:107221 Ffar4

ENSEMBL:ENSMUSG00000054200.8 Ffar4

KEGG Gene (Mus musculus):107221 Ffar4

Monarch:107221 Ffar4

NCBI Gene:107221 Ffar4

UCSC:Q7TMA4 Ffar4

Reference Transcript

RefSeq:NM_181748.2 Ffar4

Other Identifiers

10462881

107221

1439489_at

163488_at

17359113

4371959

4481308

4539945

4684024

5229198

5382500

5608697

A_52_P503663

GE1563946

GO:0001818

GO:0004930

GO:0005504

GO:0005515

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005886

GO:0005929

GO:0006954

GO:0007165

GO:0007186

GO:0007200

GO:0007204

GO:0008289

GO:0008527

GO:0010008

GO:0010827

GO:0012501

GO:0016020

GO:0023052

GO:0030139

GO:0030154

GO:0031410

GO:0032691

GO:0032870

GO:0036321

GO:0042277

GO:0042995

GO:0043066

GO:0043226

GO:0043950

GO:0045444

GO:0045669

GO:0046879

GO:0050728

GO:0050872

GO:0050873

GO:0050877

GO:0050912

GO:0055085

GO:0060089

GO:0060170

GO:0070094

GO:0070374

GO:0090275

GO:0090336

GO:0120162

GO:1990763

ILMN_2746895

mMC017059

Participates

as an input of

GPR120 is a receptor for unsaturated long-chain free fatty acids (Mus musculus)

as a member of

GPCRs that activate Gq/11 [plasma membrane] (Mus musculus)

as a component of

Gpr120:Fatty acid [plasma membrane] (Mus musculus)

Inferred From

FFAR4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_861413.1

ZINC - Substances

FFAR4_MOUSE

ZINC target

Q7TMA4

Ensembl

ENSMUSP00000063660, ENSMUST00000067098, ENSMUSG00000054200

PRO

Q7TMA4

ZINC - Predictions - Purchasable

FFAR4_MOUSE

MGI

2147577

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q91YI4 Arrb2	3	Arrb2 [cytosol] (R-MMU-6783000) Arrb2 [cytosol] (R-MMU-5632462) Arrb2 [cytosol] (R-MMU-416464)	0.556	4