CHL1 interacts with beta1 integrins

Stable Identifier
R-MMU-445068
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
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CHL1 interacts with beta1 integrins

CHL1 interacts with alpha1beta1/alpha2beta1 integrins in cis on the cell surface and promotes intracellular signaling, which stimulates cell migration on extracellular matrix proteins such as collagen-I. The integrin interaction motif, DGEA in the Ig6 domain of CHL1, is necessary to potentiate migration to collagen-I. CHL1 interacts with integrins to mediate radial migration of neural precursors in the development neocortex, and suppresses neuronal branching during migration.

Literature References
PubMed ID Title Journal Year
12721290 Close homolog of L1 is an enhancer of integrin-mediated cell migration

Buhusi, M, Midkiff, BR, Gates, AM, Richter, M, Schachner, M, Maness, PF

J Biol Chem 2003
Participants
Orthologous Events
Authored
Reviewed
Created