Reactome | phospho-Camk2a [cytosol]

phospho-Camk2a [cytosol]

Stable Identifier

R-MMU-445368

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

p-T286-CAMK2A, P11798

Locations in the PathwayBrowser

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Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Interferon Signaling (Mus musculus)
    - Interferon gamma signaling (Mus musculus)
      - Phosphorylation of STAT1 at Ser727 (Mus musculus)
        
        CaMKII and PKC-delta [cytosol] (Mus musculus)
        
        CaMKII [cytosol] (Mus musculus)
        
        CaMKII alpha/beta [cytosol] (Mus musculus)
        
        phospho-Camk2a [cytosol] (Mus musculus)

Neuronal System (Mus musculus)

- Transmission across Chemical Synapses (Mus musculus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Mus musculus)
    - Activation of NMDA receptors and postsynaptic events (Mus musculus)
      - Unblocking of NMDA receptors, glutamate binding and activation (Mus musculus)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Mus musculus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Mus musculus)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Mus musculus)
        
        p-T286-CaMKII dodecamer [cytosol] (Mus musculus)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Mus musculus)
        
        phospho-Camk2a [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P11798 Camk2a

Gene Names

Camk2a

Chain

chain:1-478

Reference Genes

BioGPS Gene:12322 Camk2a

ENSEMBL:ENSMUSG00000024617 Camk2a

KEGG Gene (Mus musculus):12322 Camk2a

Monarch:12322 Camk2a

NCBI Gene:12322 Camk2a

UCSC:P11798 Camk2a

Reference Transcript

Other Identifiers

10456021

12322

1437125_at

1442707_at

1452453_a_at

1457311_at

17351001

4425033

4520844

4539395

4565848

4574891

4631009

4640259

4696434

4709748

4730362

4761049

4773839

4830875

4872454

4881418

4900908

5011353

5015782

5042957

5054277

5070234

5139398

5199713

5216450

5251383

5316802

5378763

5407055

5412755

5497170

5501446

5512686

5598604

93659_at

93660_at

A_52_P189707

A_55_P2149209

A_55_P2149215

GE1577200

GO:0003674

GO:0004672

GO:0004683

GO:0005516

GO:0005524

GO:0006464

GO:0006468

GO:0008150

GO:0016301

GO:0043167

ILMN_2596479

ILMN_2618525

ILMN_2677393

Msa.1983.0_s_at

mMC005018

Participates

as a member of

as a component of

p-T286 CAMK2A [cytosol] (Mus musculus)

Other forms of this molecule

phospho-Camk2a [plasma membrane]

p-T286-Camk2a [nucleoplasm]

phospho-Camk2a [endocytic vesicle membrane]

phospho-Camk2a [cytosol]

Camk2a [cytosol]

Inferred From

p-T286-CAMK2A [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at 286

Coordinate

286

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001273738.1, NP_803126.1, NP_033922.1

IntEnz

2.7.11.17

Ensembl

ENSMUST00000115295, ENSMUST00000102888, ENSMUSP00000099952, ENSMUSG00000024617, ENSMUSP00000110950

PRO

P11798

MGI

88256

PDB

4X3I, 1HKX

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01097 Grin2b	7	phospho-Grin2b [plasma membrane] (R-MMU-3928477) p-Nr2b [plasma membrane] (R-MMU-3928470) Grin2b [endoplasmic reticulum membrane] (R-MMU-9610361) Grin2b [plasma membrane] (R-MMU-3928478) Grin2b [transport vesicle membrane] (R-MMU-9610571) Grin2b [endoplasmic reticulum membrane] (R-MMU-9609765) Grin2b [plasma membrane] (R-MMU-419558)	0.848	7
UniProt:Q62108 Dlg4	3	Dlg4 [endocytic vesicle membrane] (R-MMU-416847) SAP-90 [plasma membrane] (R-MMU-443606) Dlg4 [cytosol] (R-MMU-6794267)	0.623	4
UniProt:Q00960 Grin2b	7	p-Y1472-Grin2b [plasma membrane] (R-RNO-9032617) phospho-Grin2b [plasma membrane] (R-RNO-3928477) Grin2b [endoplasmic reticulum membrane] (R-RNO-9609846) Grin2b [endoplasmic reticulum membrane] (R-RNO-9609765) p-Y-Grin2b [plasma membrane] (R-RNO-9628248) Grin2b [plasma membrane] (R-RNO-419558) Grin2b [plasma membrane] (R-RNO-6794241)	0.602	3
UniProt:P35438 Grin1	3	Grin1 [endoplasmic reticulum membrane] (R-MMU-9610359) Grin1 [plasma membrane] (R-MMU-3928395) Grin1 [transport vesicle membrane] (R-MMU-9610566)	0.597	4
UniProt:P70587 Lrrc7	4	Lrrc7 [extracellular region] (R-RNO-6799681) Lrrc7 [cytosol] (R-RNO-9611392) Lrrc7 [specific granule lumen] (R-RNO-6799616) Lrrc7 [cytosol] (R-RNO-9611351)	0.544	2