Activation of Phospholipase C beta1 by G(q)alpha:GTP

Stable Identifier
R-MMU-445860
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Activation of Phospholipase C beta1 by G(q)alpha:GTP

The G(q)alpha subunit bound to GTP interacts with Phospholipase C beta1 and activates its lipase activity. Analysis by Forster resonance energy transfer indicates that the G(q)alpha and PLC beta1 may remain in close proximity throughout the activation cycle.

Literature References
PubMed ID Title Journal Year
9931014 Determination of the affinities between heterotrimeric G protein subunits and their phospholipase C-beta effectors

Runnels, LW, Scarlata, SF

Biochemistry 1999
10393909 Selective interaction of the C2 domains of phospholipase C-beta1 and -beta2 with activated Galphaq subunits: an alternative function for C2-signaling modules

Wang, T, Pentyala, S, Elliott, JT, Dowal, L, Gupta, E, Rebecchi, MJ, Scarlata, S

Proc Natl Acad Sci U S A 1999
16754659 Stable association between G alpha(q) and phospholipase C beta 1 in living cells

Dowal, L, Provitera, P, Scarlata, S

J Biol Chem 2006
18515384 Galphaq binds two effectors separately in cells: evidence for predetermined signaling pathways

Golebiewska, U, Scarlata, S

Biophys J 2008
19361438 A self-scaffolding model for G protein signaling

Wang, J, Golebiewska, U, Scarlata, S

J Mol Biol 2009
Participants
Orthologous Events
Authored
Reviewed
Created