Activation of Phospholipase C beta1 by G(q)alpha:GTP

Stable Identifier
R-MMU-445860
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activation of Phospholipase C beta1 by G(q)alpha:GTP
The G(q)alpha subunit bound to GTP interacts with Phospholipase C beta1 and activates its lipase activity. Analysis by Forster resonance energy transfer indicates that the G(q)alpha and PLC beta1 may remain in close proximity throughout the activation cycle.
Literature References
PubMed ID Title Journal Year
10393909 Selective interaction of the C2 domains of phospholipase C-beta1 and -beta2 with activated Galphaq subunits: an alternative function for C2-signaling modules

Scarlata, S, Rebecchi, MJ, Wang, T, Pentyala, S, Elliott, JT, Dowal, L, Gupta, E

Proc Natl Acad Sci U S A 1999
9931014 Determination of the affinities between heterotrimeric G protein subunits and their phospholipase C-beta effectors

Runnels, LW, Scarlata, SF

Biochemistry 1999
16754659 Stable association between G alpha(q) and phospholipase C beta 1 in living cells

Scarlata, S, Provitera, P, Dowal, L

J Biol Chem 2006
18515384 Galphaq binds two effectors separately in cells: evidence for predetermined signaling pathways

Scarlata, S, Golebiewska, U

Biophys J 2008
19361438 A self-scaffolding model for G protein signaling

Scarlata, S, Golebiewska, U, Wang, J

J Mol Biol 2009
Participants
Input
Output
Orthologous Events
Gq alpha activates Phospholipase C beta (Homo sapiens)
Authored
May, B  (2009-11-06)
Reviewed
May, B  (2009-11-06)
Created
May, B  (2009-11-06)
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