Opening of Low Conductance Potassium Channels

Stable Identifier
R-MMU-446503
Type
Reaction [omitted]
Species
Mus musculus
Compartment
plasma membrane
General
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Opening of Low Conductance Potassium Channels

Epinephrine causes hyperpolarization of pancreatic beta cells in mice by activating (opening) an unidentified potassium channel. In rat pancreatic beta cells this channel appears to be ATP-sensitive, but a knockout of the mouse ATP-sensitive potassium channel does not abolish the effect of epinephrine on potassium conductance.

Literature References
PubMed ID Title Journal Year
1898674 Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells

Rorsman, P, Bokvist, K, Ammälä, C, Arkhammar, P, Berggren, PO, Larsson, O, Wåhlander, K

Nature 1991
14613926 Epinephrine-induced hyperpolarization of islet cells without KATP channels

Sieg, A, Su, J, Muñoz, A, Buchenau, M, Nakazaki, M, Aguilar-Bryan, L, Bryan, J, Ullrich, S

Am J Physiol Endocrinol Metab 2004
18162464 Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel

Zhao, Y, Fang, Q, Straub, SG, Sharp, GW

J Biol Chem 2008
Participants
Input
Output
Orthologous Events
Low conductance potassium channels in pancreatic beta cells open in response to epinephrine (Homo sapiens)
Authored
May, B  (2009-11-13)
Reviewed
May, B  (2009-11-13)
Created
May, B  (2009-11-13)
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