Phosphorylation of E47 by p38 MAPK

Stable Identifier
R-MMU-448953
Type
Reaction
Species
Mus musculus
Compartment
General
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Phosphorylation of E47 by p38 MAPK

p38 MAPK plays a fundamental role in the transition of myoblasts to different myocytes. Activated p38 MAPK phosphorylates E12/E47, a member of the E protein subfamily of bHLH proteins. p38 MAPK in particular phosphorylates Ser140 of E47. Its been observed that phosphorylation of E47 improves its ability to form heterodimers with Myod transcription factor.

Literature References
PubMed ID Title Journal Year
15719023 E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription

Lluis, F, Ballestar, E, Suelves, M, Esteller, M, Muñoz-Cánoves, P

EMBO J 2005
15572127 Positive regulation of myogenic bHLH factors and skeletal muscle development by the cell surface receptor CDO

Cole, F, Zhang, W, Geyra, A, Kang, JS, Krauss, RS

Dev Cell 2004
Participants
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of phospho-MAPK p38 alpha/beta [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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