Phosphorylation of E47 by p38 MAPK

Stable Identifier
R-MMU-448953
Type
Reaction [transition]
Species
Mus musculus
Compartment
nuclear envelope
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of E47 by p38 MAPK
p38 MAPK plays a fundamental role in the transition of myoblasts to different myocytes. Activated p38 MAPK phosphorylates E12/E47, a member of the E protein subfamily of bHLH proteins. p38 MAPK in particular phosphorylates Ser140 of E47. Its been observed that phosphorylation of E47 improves its ability to form heterodimers with Myod transcription factor.
Literature References
PubMed ID Title Journal Year
15572127 Positive regulation of myogenic bHLH factors and skeletal muscle development by the cell surface receptor CDO

Geyra, A, Kang, JS, Cole, F, Zhang, W, Krauss, RS

Dev Cell 2004
15719023 E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription

Muñoz-Cánoves, P, Lluis, F, Suelves, M, Esteller, M, Ballestar, E

EMBO J 2005
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of phospho-MAPK p38 alpha/beta [cytosol]

Physical Entity
phospho-MAPK p38 alpha/beta [cytosol] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of E proteins by p38 MAPK (Homo sapiens)
Authored
Garapati, P V  (2008-08-11)
Reviewed
Krauss, RS  (2010-02-09)
Created
Garapati, P V  (2009-11-26)
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