Neogenin:Netrin-3 binds CDO complex

Stable Identifier
R-MMU-449201
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Neogenin:Netrin-3 binds CDO complex
CDO selectively binds to neogenin in a cis fashion and this interaction involves extracellular domains of both proteins. CDO is essential in mediating netrin-3-induced differentiation of myoblasts by neogenin. Neogenin and netrin-3 stimulate myotube formation and enhance myogenic bHLH-and NFAT-dependent transcription.
Literature References
PubMed ID Title Journal Year
15520228 Netrins and neogenin promote myotube formation

Cole, F, Kang, JS, Feinleib, JL, Yi, MJ, Zhang, W, Krauss, RS

J Cell Biol 2004
19812254 Neogenin regulates skeletal myofiber size and focal adhesion kinase and extracellular signal-regulated kinase activities in vivo and in vitro

Kang, JS, Bae, GU, Lee, HJ, Hong, M, Tessier-Lavigne, M, Yang, YJ, Krauss, RS, Jiang, G

Mol Biol Cell 2009
17137827 Neogenin: one receptor, many functions

Key, B, Wilson, NH

Int J Biochem Cell Biol 2007
Participants
Input
Output
Orthologous Events
Neogenin:Netrin-3 binds CDO complex (Homo sapiens)
Authored
Garapati, P V  (2008-08-11)
Reviewed
Krauss, RS  (2010-02-09)
Created
Garapati, P V  (2009-12-01)
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