Neogenin:Netrin-3 binds CDO complex

Stable Identifier
R-MMU-449201
Type
Reaction
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Neogenin:Netrin-3 binds CDO complex

CDO selectively binds to neogenin in a cis fashion and this interaction involves extracellular domains of both proteins. CDO is essential in mediating netrin-3-induced differentiation of myoblasts by neogenin. Neogenin and netrin-3 stimulate myotube formation and enhance myogenic bHLH-and NFAT-dependent transcription.

Literature References
PubMed ID Title Journal Year
19812254 Neogenin regulates skeletal myofiber size and focal adhesion kinase and extracellular signal-regulated kinase activities in vivo and in vitro

Bae, GU, Yang, YJ, Jiang, G, Hong, M, Lee, HJ, Tessier-Lavigne, M, Kang, JS, Krauss, RS

Mol Biol Cell 2009
15520228 Netrins and neogenin promote myotube formation

Kang, JS, Yi, MJ, Zhang, W, Feinleib, JL, Cole, F, Krauss, RS

J Cell Biol 2004
17137827 Neogenin: one receptor, many functions

Wilson, NH, Key, B

Int J Biochem Cell Biol 2007
Participants
Orthologous Events
Authored
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