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phospho-p-S218,T222-MAP2K3 [nucleoplasm]
Stable Identifier
R-MMU-450229
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
O09110
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular Senescence (Mus musculus)
Oxidative Stress Induced Senescence (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-17 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Innate Immune System (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:O09110
Reference Genes
BioGPS Gene:26397
ENSEMBL:ENSMUSG00000018932
ENSEMBL:ENSMUSG00000018932.10
KEGG Gene (Mus musculus):26397
Monarch:26397
NCBI Gene:26397
UCSC:O09110
Reference Transcript
RefSeq:NM_008928.4
Other Identifiers
10376733
1425456_a_at
1451714_a_at
17250533
26397
4493378
4547090
4584527
4709038
4755508
4794175
4842578
4925364
4927632
5014117
5110502
5145196
5243727
5276134
5365878
5520623
5536155
93314_g_at
93315_at
A_51_P272817
D87115_s_at
GE39232
GO:0000165
GO:0000166
GO:0001817
GO:0001934
GO:0002931
GO:0003012
GO:0003013
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0004713
GO:0005515
GO:0005524
GO:0006351
GO:0006355
GO:0006468
GO:0006954
GO:0007507
GO:0016301
GO:0016310
GO:0016740
GO:0019901
GO:0023052
GO:0031098
GO:0035331
GO:0035924
GO:0036211
GO:0038066
GO:0043410
GO:0043536
GO:0045893
GO:0048856
GO:0048870
GO:0051770
GO:0060048
GO:0071222
GO:0072709
GO:0106310
GO:0140096
ILMN_2659644
mMC013662
Participates
as a member of
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)
Other forms of this molecule
MAP2K3 [cytosol]
phospho-p-S218,T222-MAP2K3 [cytosol]
Inferred From
p-S218,T222-MAP2K3 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 218 (in Homo sapiens)
Coordinate
218
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 222 (in Homo sapiens)
Coordinate
222
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_032954.1
Ensembl
ENSMUSG00000018932
,
ENSMUST00000019076
,
ENSMUSP00000019076
PRO
O09110
MGI
1346868
PDB
1LEZ
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