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Phospho Mek1 [cytosol]
Stable Identifier
R-MMU-451693
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Dual specificity mitogen-activated protein kinase kinase 1, Map2k1, MP2K1_MOUSE
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
L1CAM interactions (Mus musculus)
Signal transduction by L1 (Mus musculus)
MAP2K1 phosphorylates MAPK3 (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-2S-MAP2K1:MAPK3 [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF-independent MAPK1/3 activation (Mus musculus)
MAPK3 (ERK1) activation (Mus musculus)
Dissociation of p-T,Y-MAPK3:MAP2K1 (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
Inactivation of MAP2K1 by CDK1 (Mus musculus)
MAP2K1 [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
MAP2K1 binds MAPK3 (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-2S-MAP2K1:MAPK3 [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
MAP2K1 phosphorylates MAPK3 (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-2S-MAP2K1:MAPK3 [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
MAP2K and MAPK activation (Mus musculus)
Dissociation of RAS:RAF complex (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
IL17RD binds p-2S MAP2Ks and MAPKs (Mus musculus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Mus musculus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Mus musculus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
MAP2Ks phosphorylate MAPKs (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
RAF phosphorylates MAP2K dimer (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
Negative regulation of MAPK pathway (Mus musculus)
Negative feedback regulation of MAPK pathway (Mus musculus)
Activated MAPKs phosphorylate MAP2K1 (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
RAF activation (Mus musculus)
Phosphorylation of RAF (Mus musculus)
RAF activating kinases [plasma membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
Signalling to ERKs (Mus musculus)
Prolonged ERK activation events (Mus musculus)
Frs2-mediated activation (Mus musculus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Mus musculus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
Dissociation of phosphorylated MAP2Ks and MAPKs (Mus musculus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Mus musculus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Mus musculus)
p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
Phospho Mek1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P31938 Map2k1
Gene Names
Map2k1, Mek1, Prkmk1
Chain
chain:1-393
Reference Genes
BioGPS Gene:26395 Map2k1
ENSEMBL:ENSMUSG00000004936.9 Map2k1
KEGG Gene (Mus musculus):26395 Map2k1
Monarch:26395 Map2k1
NCBI Gene:26395 Map2k1
UCSC:P31938 Map2k1
Reference Transcript
RefSeq:NM_008927.3 Map2k1
Other Identifiers
10594447
1416351_at
17528160
26395
4421601
4466788
4511579
4542044
4699752
4931127
5131293
5332431
5372086
5456287
5457116
5527956
5533806
5541097
92585_at
A_51_P241074
A_65_P17605
GE40374
GE42551
GO:0000165
GO:0000166
GO:0002376
GO:0003012
GO:0003013
GO:0003056
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0004712
GO:0004713
GO:0005078
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005768
GO:0005769
GO:0005770
GO:0005783
GO:0005794
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0005925
GO:0005938
GO:0006351
GO:0006355
GO:0006468
GO:0006914
GO:0006979
GO:0007018
GO:0007155
GO:0007507
GO:0008285
GO:0008286
GO:0010508
GO:0010628
GO:0010629
GO:0012501
GO:0014044
GO:0014069
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0019901
GO:0021697
GO:0023052
GO:0030154
GO:0030182
GO:0030216
GO:0030295
GO:0030335
GO:0030424
GO:0030425
GO:0030878
GO:0031267
GO:0031410
GO:0031435
GO:0032402
GO:0032839
GO:0032872
GO:0032968
GO:0034111
GO:0035987
GO:0036211
GO:0038133
GO:0042552
GO:0043204
GO:0043226
GO:0043410
GO:0043539
GO:0044342
GO:0044877
GO:0045893
GO:0045933
GO:0046579
GO:0047496
GO:0048009
GO:0048313
GO:0048471
GO:0048538
GO:0048678
GO:0048679
GO:0048812
GO:0048856
GO:0048870
GO:0050772
GO:0051384
GO:0055086
GO:0060020
GO:0060090
GO:0060324
GO:0060425
GO:0060440
GO:0060502
GO:0060674
GO:0060711
GO:0070328
GO:0070371
GO:0070372
GO:0070374
GO:0090170
GO:0090398
GO:0097110
GO:0098696
GO:0098772
GO:0098978
GO:0106310
GO:0140096
GO:1901135
GO:1903226
GO:1903298
GO:2000641
GO:2001171
ILMN_2714534
L02526_s_at
mMC014391
Participates
as a member of
MAP2K1 [cytosol] (Mus musculus)
Phospho Mek1, Phospho Sek1 [cytosol] (Mus musculus)
as an output of
Dissociation of p-T,Y-MAPK3:MAP2K1 (Mus musculus)
as an input of
MAP2K1 binds MAPK3 (Mus musculus)
as a component of
p-2S-MAP2K1:MAPK3 [cytosol] (Mus musculus)
p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol] (Mus musculus)
p-S218,S222 MAP2K1 dimer [cytosol] (Mus musculus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Mus musculus)
Other forms of this molecule
phospho-p-S,218, S222,T292 MAP2K1 [cytosol]
phospho-p-T286,T292-MAP2K1 [cytosol]
phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol]
Mek1 [cytosol]
Inferred From
p-S218,S222-MAP2K1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 218
Coordinate
218
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 222
Coordinate
222
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_032953.1
ZINC - Substances
MP2K1_MOUSE
Ensembl
ENSMUSP00000005066
,
ENSMUST00000005066
,
ENSMUSG00000004936
ZINC target
P31938
PRO
P31938
ZINC - Predictions - Purchasable
MP2K1_MOUSE
MGI
1346866
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13526 PIN1
2
PIN1 [cytosol]
(R-HSA-9626823)
PIN1 [nucleoplasm]
(R-HSA-936016)
0.558
4
UniProt:Q9ESN9-2 MAPK8IP3
0.499
3
UniProt:P35438 Grin1
3
Grin1 [plasma membrane]
(R-MMU-3928395)
Grin1 [endoplasmic reticulum membrane]
(R-MMU-9610359)
Grin1 [transport vesicle membrane]
(R-MMU-9610566)
0.462
2
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