Nephrin binds CD2AP

Stable Identifier
R-MMU-451756
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Nephrin binds CD2AP
CD2-associated protein (CD2AP) is an adapter molecule of the immunoglobulin superfamily that was first identified as an SH3-containing protein that binds to the cytoplasmic domain of CD2. In the glomerulus, CD2AP is located in the cytoplasm beneath the slit-diaphragm, where it binds to the cytoplasmic domain of nephrin. CD2AP acts as a linker protein and may be involved in connecting nephrin to the actin cytoskeleton in podocytes, although direct evidence of this is still lacking. Interaction with CD2AP might be important in the steady-state situation. In addition CD2AP can facilitate nephrin-induced PI3K-AKT signaling, a pathway that has been shown to be important for nephrin-mediated actin reorganization in podocytes and protection of podocytes from apoptosis.
Literature References
PubMed ID Title Journal Year
12832477 Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling

Huber, TB, Hartleben, B, Kim, J, Schmidts, M, Schermer, B, Keil, A, Egger, L, Lecha, RL, Borner, C, Pavenstädt, H, Shaw, AS, Walz, G, Benzing, T

Mol Cell Biol 2003
11733379 CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain

Shih, NY, Li, J, Cotran, R, Mundel, P, Miner, JH, Shaw, AS

Am J Pathol 2001
10997929 CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere

Li, C, Ruotsalainen, V, Tryggvason, K, Shaw, AS, Miner, JH

Am J Physiol Renal Physiol 2000
Participants
Input
Output
Orthologous Events
Nephrin binds CD2AP (Homo sapiens)
Authored
de Bono, B  (2008-02-26)
Garapati, P V  (2008-02-26)
Reviewed
Huber, TB  (2010-05-20)
Grahammer, Florian  (2010-05-20)
Created
Garapati, P V  (2010-01-11)
Cite Us!