Cbx4 (Pc2) Sumoylates Dnmt3a with Sumo1

Stable Identifier
R-MMU-4655387
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cbx4 (Pc2) Sumoylates Dnmt3a with Sumo1
Cbx4 (Pc2) sumoylates Dnmt3a with Sumo1 at more than one site in the N-terminal (regulatory) domain (Ling et al. 2004, Li et al. 2007). Sumoylation reduces the interaction of Dnmt3a with Hdac1 and Hdac2.
Literature References
PubMed ID Title Journal Year
17439403 Polycomb protein Cbx4 promotes SUMO modification of de novo DNA methyltransferase Dnmt3a

Li, B, Zhou, J, Liu, P, Hu, J, Jin, H, Shimono, Y, Takahashi, M, Xu, G

Biochem. J. 2007
14752048 Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription

Ling, Y, Sankpal, UT, Robertson, AK, McNally, JG, Karpova, T, Robertson, KD

Nucleic Acids Res. 2004
Participants
Input
Output
Catalyst Activity

SUMO transferase activity of Cbx4 [nucleoplasm]

Physical Entity
Cbx4 [nucleoplasm] (Mus musculus)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 (Homo sapiens)
Authored
May, B  (2013-09-28)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-03)
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