Pias1,2-2 Sumoylate Pparg with Sumo1

Stable Identifier
R-MMU-4717507
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Pias1,2-2 Sumoylate Pparg with Sumo1
Pias1,2-1 sumoylate Pparg with Sumo1 at lysine-107 and lysine-365 (Floyd and Stephens 2004, Ohshima et al. 2004, Yamashita et al. 2004, Pascual et al. 2005, Jennewein et al. 2008). Sumoylation decreases the transcriptional coactivation activity of Pparg. Sumoylation at lysine-365 is dependent on ligand-binding and causes Pparg to recruit corepressors such as Ncor and Hdac3.
Literature References
PubMed ID Title Journal Year
15123625 Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification

Ohshima, T, Koga, H, Shimotohno, K

J. Biol. Chem. 2004
15229330 Control of peroxisome proliferator-activated receptor gamma2 stability and activity by SUMOylation

Floyd, ZE, Stephens, JM

Obes. Res. 2004
18832723 Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines

Jennewein, C, Kuhn, AM, Schmidt, MV, Meilladec-Jullig, V, von Knethen, A, Gonzalez, FJ, Brüne, B

J. Immunol. 2008
15507114 The transactivating function of peroxisome proliferator-activated receptor gamma is negatively regulated by SUMO conjugation in the amino-terminal domain

Yamashita, D, Yamaguchi, T, Shimizu, M, Nakata, N, Hirose, F, Osumi, T

Genes Cells 2004
16127449 A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma

Pascual, G, Fong, AL, Ogawa, S, Gamliel, A, Li, AC, Perissi, V, Rose, DW, Willson, TM, Rosenfeld, MG, Glass, CK

Nature 2005
Participants
Input
Output
Catalyst Activity

SUMO transferase activity of Pias1,2-2 [nucleoplasm]

Physical Entity
Pias1,2-2 [nucleoplasm] (Mus musculus)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS1,2-2 SUMOylate PPARG with SUMO1 (Homo sapiens)
Authored
May, B  (2013-10-11)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-18)
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