Pias1,2-2 Sumoylate Pparg with Sumo1

Stable Identifier
Reaction [transition]
Mus musculus
SVG |   | PPTX  | SBGN
Pias1,2-2 Sumoylate Pparg with Sumo1

Pias1,2-1 sumoylate Pparg with Sumo1 at lysine-107 and lysine-365 (Floyd and Stephens 2004, Ohshima et al. 2004, Yamashita et al. 2004, Pascual et al. 2005, Jennewein et al. 2008). Sumoylation decreases the transcriptional coactivation activity of Pparg. Sumoylation at lysine-365 is dependent on ligand-binding and causes Pparg to recruit corepressors such as Ncor and Hdac3.

Literature References
PubMed ID Title Journal Year
15229330 Control of peroxisome proliferator-activated receptor gamma2 stability and activity by SUMOylation

Floyd, ZE, Stephens, JM

Obes. Res. 2004
15123625 Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification

Ohshima, T, Koga, H, Shimotohno, K

J. Biol. Chem. 2004
18832723 Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines

Jennewein, C, Kuhn, AM, Schmidt, MV, Meilladec-Jullig, V, von Knethen, A, Gonzalez, FJ, BrĂ¼ne, B

J. Immunol. 2008
15507114 The transactivating function of peroxisome proliferator-activated receptor gamma is negatively regulated by SUMO conjugation in the amino-terminal domain

Yamashita, D, Yamaguchi, T, Shimizu, M, Nakata, N, Hirose, F, Osumi, T

Genes Cells 2004
16127449 A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma

Pascual, G, Fong, AL, Ogawa, S, Gamliel, A, Li, AC, Perissi, V, Rose, DW, Willson, TM, Rosenfeld, MG, Glass, CK

Nature 2005
Catalyst Activity

SUMO transferase activity of Pias1,2-2 [nucleoplasm]

Orthologous Events
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