Pias4 Sumoylates Nr4a2 with Sumo2,3

Stable Identifier
R-MMU-4755534
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Pias4 Sumoylates Nr4a2 with Sumo2,3

Pias4 sumoylates Nr4a2 (Nurr1) with Sumo2,3 at lysine-558 and lysine-577 (Saijo et al. 2009). Sumoylated Nr4a2 interacts with the Co-REST complex to transrepress promoters of genes involved in inflammation.

Literature References
PubMed ID Title Journal Year
19345186 A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death

Saijo, K, Winner, B, Carson, CT, Collier, JG, Boyer, L, Rosenfeld, MG, Gage, FH, Glass, CK

Cell 2009
Participants
Catalyst Activity

SUMO transferase activity of Pias4 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
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