Pias4 Sumoylates Nr4a2 with Sumo2,3

Stable Identifier
R-MMU-4755534
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
General
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PNG
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 | PPTX  | SBGN
Pias4 Sumoylates Nr4a2 with Sumo2,3

Pias4 sumoylates Nr4a2 (Nurr1) with Sumo2,3 at lysine-558 and lysine-577 (Saijo et al. 2009). Sumoylated Nr4a2 interacts with the Co-REST complex to transrepress promoters of genes involved in inflammation.

Literature References
PubMed ID Title Journal Year
19345186 A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death

Saijo, K, Winner, B, Carson, CT, Collier, JG, Boyer, L, Rosenfeld, MG, Gage, FH, Glass, CK

Cell 2009
Participants
Input
Output
Catalyst Activity

SUMO transferase activity of Pias4 [nucleoplasm]

Physical Entity
Pias4 [nucleoplasm] (Mus musculus)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS4 SUMOylates NR4A2 with SUMO2,3 (Homo sapiens)
Authored
May, B  (2013-10-20)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-25)
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