Beta-TrCP (Btrc) binds phosphorylated Per

Stable Identifier
R-MMU-508749
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
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Beta-TrCP (Btrc) binds phosphorylated Per
By homology with human Beta-TrCP1, mouse Beta-TrCP (Btrc) is an F-box type component of a particular SKP/CUL/F-Box (SCF) E3 ubiquitin ligase. In human cells Beta-TrCP1 interacts specifically with phosphorylated PER proteins and directs their polyubiquitination.
Literature References
PubMed ID Title Journal Year
18782782 The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2

Ishida, N, Kozono, Y, Oishi, K, Ohsaki, K, Nakayama, KI, Nakayama, K

J Biochem 2008
17876059 Beta-TrCP1-mediated degradation of PERIOD2 is essential for circadian dynamics

Vanselow, K, Westermark, PO, Herzel, H, Maier, B, Reischl, S, Kramer, A, Thierfelder, N

J Biol Rhythms 2007
15767683 Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation

Eide, EJ, Giovanni, A, Vielhaber, EL, Hurst, W, Woolf, MF, Virshup, DM, Camacho, F, Kang, H, Woolf, P

Mol Cell Biol 2005
Participants
Input
Output
Orthologous Events
Beta-TrCP1 binds phosphorylated PER proteins (Homo sapiens)
Authored
May, B  (2010-02-20)
Reviewed
Delaunay, F  (2010-06-23)
Kay, SA  (2010-06-23)
Hirota, T  (2010-06-23)
Albrecht, U  (2010-06-23)
Created
May, B  (2010-02-16)
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