Reactome | Mta2 [nucleoplasm]

Mta2 [nucleoplasm]

Stable Identifier

R-MMU-5096453

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Metastasis-associated protein MTA2, MTA2_MOUSE

Locations in the PathwayBrowser

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Chromatin organization (Mus musculus)

- Chromatin modifying enzymes (Mus musculus)
  - HDACs deacetylate histones (Mus musculus)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Mus musculus)
      - HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Mus musculus)
        
        Mta2 [nucleoplasm] (Mus musculus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Mus musculus)
        
        HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Mus musculus)
        
        Mta2 [nucleoplasm] (Mus musculus)
    - HDAC1:2-containing complex deacetylate histones (Mus musculus)
      - HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Mus musculus)
        
        Mta2 [nucleoplasm] (Mus musculus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Mus musculus)
        
        HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Mus musculus)
        
        Mta2 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase I Transcription (Mus musculus)
  - RNA Polymerase I Promoter Clearance (Mus musculus)
    - RNA Polymerase I Transcription Initiation (Mus musculus)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Mus musculus)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Mus musculus)
        
        Mta2 [nucleoplasm] (Mus musculus)
- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - Regulation of TP53 Activity (Mus musculus)
        
        Regulation of TP53 Activity through Acetylation (Mus musculus)
        
        MTA2-NuRD complex deacetylates TP53 (Mus musculus)
        
        MTA2-NuRD complex [nucleoplasm] (Mus musculus)
        
        Mta2 [nucleoplasm] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - PTEN Regulation (Mus musculus)
      - Regulation of PTEN gene transcription (Mus musculus)
        
        SALL4 recruits NuRD to PTEN gene (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Mus musculus)
        
        Mta2 [nucleoplasm] (Mus musculus)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Mus musculus)
        
        SALL4:NuRD [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Mus musculus)
        
        Mta2 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9R190 Mta2

Gene Names

Mta2, Mta1l1

Chain

chain:1-668

Reference Genes

BioGPS Gene:23942 Mta2

ENSEMBL:ENSMUSG00000071646 Mta2

KEGG Gene (Mus musculus):23942 Mta2

Monarch:23942 Mta2

NCBI Gene:23942 Mta2

UCSC:Q9R190 Mta2

Reference Transcript

RefSeq:NM_011842.3 Mta2

Other Identifiers

10461334

1423165_a_at

17357338

23942

4314554

4513994

4536583

4539289

4595952

4633943

4643865

4675850

4758647

4895658

4899116

4905504

4910360

4910617

5053774

5148244

5208691

5265025

5272277

5300818

5323814

5353572

5376548

5417937

5469116

5486014

5571505

96003_at

A_51_P164207

A_51_P181851

A_52_P43972

GE42692

GO:0000228

GO:0003674

GO:0003677

GO:0003682

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0006355

GO:0008150

GO:0008270

GO:0009058

GO:0016581

GO:0032991

GO:0034641

GO:0043167

GO:0043226

GO:0043565

ILMN_1243492

ILMN_2595774

ILMN_2830979

mMC012159

mMC019333

Participates

as a member of

as a component of

MTA2-NuRD complex [nucleoplasm] (Mus musculus)

Inferred From

MTA2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_035972.3

Ensembl

ENSMUSG00000071646, ENSMUSP00000093959, ENSMUST00000096240

PRO

Q9R190

MGI

1346340

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P70288 Hdac2	2	Hdac2 [nucleoplasm] (R-MMU-573366) Hdac2 [nucleoplasm] (R-MMU-4615958)	0.708	7
UniProt:O09106 Hdac1	2	Hdac1 [nucleoplasm] (R-MMU-573340) Hdac1 [nucleoplasm] (R-MMU-4616030)	0.708	7
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.527	2
UniProt:Q6PDQ2 Chd4	2	Chd4 [nucleoplasm] (R-MMU-3702078) Chd4 [nucleoplasm] (R-MMU-5096464)	0.527	2
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.527	2
UniProt:P12813	2	Nr4a1 [nucleoplasm] (R-MMU-199831) phospho-Nr4a1 [nucleoplasm] (R-MMU-199846)	0.499	2