Reactome | phospho-Dvl2 [clathrin-coated endocytic vesicle]

phospho-Dvl2 [clathrin-coated endocytic vesicle]

Stable Identifier

R-MMU-5138444

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

clathrin-coated endocytic vesicle

Synonyms

p-DVL2, Q60838

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by WNT (Mus musculus)
  - Beta-catenin independent WNT signaling (Mus musculus)
    - PCP/CE pathway (Mus musculus)
      - WNT5A-dependent internalization of FZD4 (Mus musculus)
        
        WNT5A:FZD4 is endocytosed (Mus musculus)
        
        WNT5A:FZD4:p-DVL2:AP-2:clathrin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        phospho-Dvl2 [clathrin-coated endocytic vesicle] (Mus musculus)

External Reference Information

External Reference

UniProt:Q60838

Gene Names

Dvl2

Reference Genes

BioGPS Gene:13543 Dvl2

ENSEMBL:ENSMUSG00000020888

KEGG Gene (Mus musculus):13543 Dvl2

Monarch:13543 Dvl2

NCBI Gene:13543 Dvl2

UCSC:Q60838 Dvl2

Reference Transcript

RefSeq:NM_007888.3 Dvl2

Other Identifiers

100495_at

10377704

13543

1417207_at

1448616_at

17251875

17251898

4343036

4400789

4476667

4537071

4589520

4660792

4690911

4748892

4891337

4894707

5024734

5079646

5087732

5132982

5149234

5168033

5197159

5215966

5328607

5366861

5434006

5456603

5498876

A_51_P113106

A_55_P2055864

A_55_P2055869

GE1524490

GO:0001843

GO:0001934

GO:0003007

GO:0003151

GO:0003674

GO:0005109

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005938

GO:0006351

GO:0006355

GO:0007379

GO:0007507

GO:0008104

GO:0008150

GO:0016020

GO:0016055

GO:0016235

GO:0016328

GO:0016604

GO:0019899

GO:0019901

GO:0019904

GO:0022007

GO:0022603

GO:0023052

GO:0030136

GO:0030154

GO:0030674

GO:0031267

GO:0031410

GO:0035282

GO:0035556

GO:0035567

GO:0036211

GO:0042802

GO:0043226

GO:0043507

GO:0043547

GO:0043621

GO:0044340

GO:0045177

GO:0045944

GO:0048856

GO:0051091

GO:0060029

GO:0060070

GO:0060071

GO:0061098

GO:0090103

GO:0090179

GO:0150012

ILMN_1243340

U24160_s_at

mMC003619

Participates

as a component of

WNT5A:FZD4:p-DVL2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Other forms of this molecule

Dvl2 [cytosol]

phospho-Dvl2 [cytosol]

Dvl2 [cytosol]

Inferred From

p-DVL2 [clathrin-coated endocytic vesicle] (Homo sapiens)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_031914.3

Ensembl

ENSMUSP00000099635, ENSMUSP00000019362, ENSMUSG00000020888, ENSMUST00000102575, ENSMUST00000019362, ENSMUSP00000140073, ENSMUST00000190940

PRO

Q60838

MGI

106613

PDB

3ML6, 6VCC

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q60838	5	Dvl2 [cytosol] (R-MMU-4652689) phospho-Dvl2 [clathrin-coated endocytic vesicle] (R-MMU-5138444) phospho-Dvl2 [cytosol] (R-MMU-201706) phospho-Dvl2 [cytosol] (R-MMU-3772398) Dvl2 [cytosol] (R-MMU-201694)	0.766	7
UniProt:Q91ZD4 Vangl2	2	pS5,S82,S84-Vangl2 [plasma membrane] (R-MMU-4551502) Vangl2 [plasma membrane] (R-MMU-4551496)	0.69	4
UniProt:Q155Q3 DIXC1			0.65	4
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.632	12
UniProt:Q9Y4D1-1 DAAM1			0.602	4
UniProt:Q8R4A3	1	Dact1 [cytosol] (R-MMU-4641144)	0.589	3
UniProt:Q80Z96	1	Vangl1 [plasma membrane] (R-MMU-9714275)	0.581	4
UniProt:P84092 Ap2m1	8	phospho-p-T156 AP2M1 [cytosol] (R-RNO-8856805) AP2M1 [endolysosome membrane] (R-RNO-6784828) AP2M1-2 [endocytic vesicle membrane] (R-RNO-416634) Adaptor Protein 2 mu 1 subunit [plasma membrane] (R-RNO-182057) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-RNO-2130423) AP2M1 [cytosol] (R-RNO-182227) AP2M1 [lysosomal membrane] (R-RNO-196144) AP2M1 [plasma membrane] (R-RNO-167585)	0.558	4
UniProt:P49674 CSNK1E	2	CSNK1E [cytosol] (R-HSA-205877) CSNK1E [nucleoplasm] (R-HSA-421306)	0.544	3
UniProt:Q61062	4	Dvl3 [cytosol] (R-MMU-4652688) Dvl3 [cytosol] (R-MMU-201678) phospho-Dvl3 [cytosol] (R-MMU-201680) phospho-Dvl3 [cytosol] (R-MMU-3772400)	0.463	3