Sirt1 deacetylates Taf1b in SL1 complex

Stable Identifier
R-MMU-5211233
Type
Reaction
Species
Mus musculus
Compartment
General
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Sirt1 deacetylates Taf1b in SL1 complex

Sirt1, an NAD-dependent deacetylase, deacetylates the Taf1b subunit of the SL1 complex, which regulates transcription by RNA polymerase I (Muth et al. 2001). Deacetylation of Taf1b inhibits the transcription of rRNA genes.

Literature References
PubMed ID Title Journal Year
11250901 Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription.

Muth, V, Nadaud, S, Grummt, I, Voit, R

EMBO J 2001
Participants
Catalyst Activity
Catalyst Activity
Title
NAD-dependent protein deacetylase activity of Sirt1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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