p130Cas binds Fak

Stable Identifier
R-MMU-5218849
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
p130Cas binds Fak

P130CAS (Crk-associated substrate/BCAR1) is an adaptor protein which upon phosphorylation recruits additional signaling proteins that link the scaffold to the actin cytoskeleton of the cell (Klemke at al. 1998). The C-terminal proline-rich region of Focal adhesion kinase (FAK1) spanning amino acids 712-718 binds the SH3 domain-containing region of p130CAS (Polte & Hanks 1995). P130CAS also interacts with Src-family kinases (SFKs) via its C-terminal Src-binding domain (SBD). Though FAK1 has no tyrosine kinase activity towards p130CAS, it contributes to p130CAS phosphorylation by interacting with SFKs (Ruest et al. 2001).

Literature References
PubMed ID Title Journal Year
7479864 Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas

Polte, TR, Hanks, SK

Proc. Natl. Acad. Sci. U.S.A. 1995
11604500 Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src

Ruest, PJ, Shin, NY, Polte, TR, Zhang, X, Hanks, SK

Mol. Cell. Biol. 2001
Participants
Orthologous Events
Authored
Reviewed
Created
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