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phospho-p-T357,S358-MLKL [cytosol]
Stable Identifier
R-MMU-5218903
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q9D2Y4
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Mus musculus)
Regulated Necrosis (Mus musculus)
RIPK1-mediated regulated necrosis (Mus musculus)
MLKL binds PIPs (Mus musculus)
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)
RIPK3 phosphorylates MLKL (Mus musculus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Mus musculus)
phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)
Regulation of necroptotic cell death (Mus musculus)
ITCH polyubiquitinates MLKL at K50 (Mus musculus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Mus musculus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Mus musculus)
phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)
MLKL binds FLOT1, FLOT2 (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)
MLKL binds IP4, IP5 and IP6 (Mus musculus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Mus musculus)
phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol] (Mus musculus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Mus musculus)
phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)
MLKL binds ITCH (Mus musculus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Mus musculus)
phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Mus musculus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Mus musculus)
phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)
MLKL binds PDCD6IP and SDCBP (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)
Transport of small molecules (Mus musculus)
Ion channel transport (Mus musculus)
Stimuli-sensing channels (Mus musculus)
TRP channels (Mus musculus)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)
TRPV1 transports Ca2+ from extracellular region to cytosol (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)
TRPs transport extracellular Ca2+ to cytosol (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9D2Y4
Reference Genes
BioGPS Gene:74568
ENSEMBL:ENSMUSG00000012519
ENSEMBL:ENSMUSG00000012519.15
KEGG Gene (Mus musculus):74568
Monarch:74568
NCBI Gene:74568
UCSC:Q9D2Y4
Reference Transcript
RefSeq:XM_006531442.2
RefSeq:NM_001310613.1
RefSeq:NM_029005.3
Other Identifiers
10581813
1429570_at
17513076
4380861
4385864
4576613
4590574
4664528
4714411
5056068
5133591
5489564
5502884
5517600
74568
A_51_P440535
A_55_P2046802
GE1442203
GO:0000166
GO:0003824
GO:0004672
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0007166
GO:0012501
GO:0016020
GO:0016740
GO:0019901
GO:0023052
GO:0030054
GO:0036211
GO:0042802
GO:0043226
GO:0044877
GO:0051607
GO:0065003
GO:0070207
GO:0070266
GO:0097527
GO:0097528
GO:0098542
GO:0140096
ILMN_2504397
ILMN_3006767
mMC013413
Participates
as a repeated unit of
p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
as a component of
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Mus musculus)
Other forms of this molecule
phospho-K63PolyUb-K50,p-T357,S358-MLKL [cytosol]
MLKL [cytosol]
Inferred From
p-T357,S358-MLKL [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 358 (in Homo sapiens)
Coordinate
358
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 357 (in Homo sapiens)
Coordinate
357
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001297542.1
,
NP_083281.1
,
XP_006531505.1
Ensembl
ENSMUSP00000113718
,
ENSMUSG00000012519
,
ENSMUST00000056157
,
ENSMUSP00000055521
,
ENSMUST00000120432
PRO
Q9D2Y4
MGI
1921818
PDB
4BTF
,
4M68
,
4M69
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9QZL0
8
phospho-p-S199,227, K48pUb-363-RIPK3 [cytosol]
(R-MMU-9686933)
K33polyUb-K197,302,364-RIPK3 [cytosol]
(R-MMU-9794180)
OGlcNAc-T467-RIPK3 [cytosol]
(R-MMU-9687819)
RIPK3(329-518) [cytosol]
(R-MMU-9686937)
RIPK3(1-328) [cytosol]
(R-MMU-9686917)
Ub-K55,363-RIPK3 [cytosol]
(R-MMU-9688825)
phospho-p-S199,227-RIPK3 [cytosol]
(R-MMU-5218873)
RIPK3 [cytosol]
(R-MMU-450328)
0.641
3
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