RanBP2 Sumoylates Top2a with Sumo1

Stable Identifier
R-MMU-5228515
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
RanBP2 Sumoylates Top2a with Sumo1

RanBP2 sumoylates topoisomerase Top2a with Sumo1 during interphase and mitosis (Dawlaty et al. 2008). Sumoylated Top2a is observed at centromeres and sumoylation is required for proper segregation of chromosomes (Dawlaty et al. 2008).

Literature References
PubMed ID Title Journal Year
18394993 Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha

Dawlaty, MM, Malureanu, L, Jeganathan, KB, Kao, E, Sustmann, C, Tahk, S, Shuai, K, Grosschedl, R, van Deursen, JM

Cell 2008
Participants
Catalyst Activity

SUMO transferase activity of Ranbp2 [nuclear envelope]

Orthologous Events
Authored
Reviewed
Created
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