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Phospho MKK6_MOUSE [cytosol]
Stable Identifier
R-MMU-532220
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular Senescence (Mus musculus)
Oxidative Stress Induced Senescence (Mus musculus)
MAP3K5 phosphorylates MKK3 and MKK6 (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Interferon Signaling (Mus musculus)
Antiviral mechanism by IFN-stimulated genes (Mus musculus)
PKR-mediated signaling (Mus musculus)
p-PKR dimer phosphorylates MKK6 (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
TAK1 phosphorylates MKK6 (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
Interleukin-17 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Mus musculus)
NOD1/2 Signaling Pathway (Mus musculus)
Activation of p38 MAPK (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
TAK1 phosphorylates MKK6 (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P70236 Map2k6
Gene Names
Map2k6, Prkmk6, Sapkk3
Chain
chain:1-334
Reference Genes
BioGPS Gene:26399 Map2k6
ENSEMBL:ENSMUSG00000020623.12 Map2k6
KEGG Gene (Mus musculus):26399 Map2k6
Monarch:26399 Map2k6
NCBI Gene:26399 Map2k6
UCSC:P70236 Map2k6
Reference Transcript
RefSeq:NM_011943.2 Map2k6
Other Identifiers
102828_at
102829_s_at
10382300
1426850_a_at
17257906
26399
4403440
4409333
4565096
4695474
4759041
4879865
4921184
4964398
5083954
5085712
5177632
5213143
5218285
5303196
5327804
5349441
5381059
5543732
5597608
A_51_P256093
A_52_P299915
GE33084
GO:0000165
GO:0000166
GO:0001649
GO:0001934
GO:0002931
GO:0003012
GO:0003013
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0004713
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0006468
GO:0006915
GO:0009410
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0019901
GO:0022414
GO:0022602
GO:0023052
GO:0030154
GO:0031098
GO:0032308
GO:0036211
GO:0038066
GO:0042802
GO:0043065
GO:0043226
GO:0043410
GO:0048856
GO:0051403
GO:0051770
GO:0060048
GO:0060348
GO:0072709
GO:0106310
GO:0120163
GO:0140096
ILMN_1215521
ILMN_2599748
ILMN_2623856
mMC008940
u39066_s_at
Participates
as an output of
p-PKR dimer phosphorylates MKK6 (Mus musculus)
TAK1 phosphorylates MKK6 (Mus musculus)
as a member of
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Mus musculus)
Other forms of this molecule
MAP2K6 [cytosol]
phospho-p-S207,T211-MAP2K6 [nucleoplasm]
Inferred From
p-S207,T211-MAP2K6 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 207
Coordinate
207
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 211
Coordinate
211
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_036073.1
Ensembl
ENSMUSP00000020949
,
ENSMUSG00000020623
,
ENSMUST00000020949
PRO
P70236
MGI
1346870
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