Dnmt3b:Dnmt3l methylates cytosine in DNA

Stable Identifier
R-MMU-5336380
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Dnmt3b:Dnmt3l methylates cytosine in DNA

Dnmt3b methylates the 5 position of cytosine in DNA. Dnmt3b catalyzes de novo methylation of cytosine residues (Okano et al. 1998, Hsieh 1999) in CG sequences (Hsieh 1999) and in non-CG sequences (Arand et al. 2012). Methylation of C residues in non-CG contexts is observed only in embryonic stem cells and appears to be catalyzed by Dnmt3b and Dnmt3a acting with Dnmt3l (Arand et al. 2012).

Literature References
PubMed ID Title Journal Year
22761581 In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases

Arand, J, Spieler, D, Karius, T, Branco, MR, Meilinger, D, Meissner, A, Jenuwein, T, Xu, G, Leonhardt, H, Wolf, V, Walter, J

PLoS Genet. 2012
10567546 In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b

Hsieh, CL

Mol. Cell. Biol. 1999
9662389 Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

Okano, M, Xie, S, Li, E

Nat. Genet. 1998
Participants
Catalyst Activity
Catalyst Activity
Title
DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates of Dnmt3b:Dnmt3l:Chromatin [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created