Phosphorylated Cry:Per:Kinase complex translocates to the nucleus

Stable Identifier
Reaction [omitted]
Mus musculus
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Phosphorylated Cry:Per:Kinase complex translocates to the nucleus

Cry proteins facilitate the entry of Per proteins into the nucleus. Phosphorylation of Cry and Per proteins regulates their cytoplasmic-nuclear translocation as well as their degradation. Phosphorylation of Per1 was observed to block its entry into the nucleus (Vielhaber et al. 2000), however both Per1 and Per2 showed reduced nuclear localization in mutants lacking both Csnk1d and Csnk1e kinases (Lee et al. 2009). Cry proteins act to retain Per2 in the nucleus (Yagita 2002). In wild type mice Cry and Per proteins are predominantly nuclear.

Literature References
PubMed ID Title Journal Year
10428031 mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop

Kume, K, Zylka, MJ, Sriram, S, Shearman, LP, Weaver, DR, Jin, X, Maywood, ES, Hastings, MH, Reppert, SM

Cell 1999
11591712 Nuclear export of mammalian PERIOD proteins

Vielhaber, EL, Duricka, D, Ullman, KS, Virshup, DM

J Biol Chem 2001
11875063 The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon

Eide, EJ, Vielhaber, EL, Hinz, WA, Virshup, DM

J Biol Chem 2002
11889036 Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

Yagita, K, Tamanini, F, Yasuda, M, Hoeijmakers, JH, van der Horst, GT, Okamura, H

EMBO J 2002
19948962 Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock

Lee, H, Chen, R, Lee, Y, Yoo, S, Lee, C

Proc Natl Acad Sci U S A 2009
10848614 Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon

Vielhaber, E, Eide, E, Rivers, A, Gao, ZH, Virshup, DM

Mol Cell Biol 2000
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