1,3-beta-D-glucan:p-15Y-Clec7a:Syk phosphorylates Plcg2

Stable Identifier
R-MMU-5607754
Type
Reaction [transition]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
1,3-beta-D-glucan:p-15Y-Clec7a:Syk phosphorylates Plcg2
Activation of SYK triggers multiple cascades, which induces NF-kB activation through a CARD9-dependent pathway. Phospholipase C-gamma 2 (PLCG2) is one of the key signaling components of the CLEC7A (Dectin-1) pathway that connects SYK activation to CARD9 recruitment. PLCG2 is activated upon CLEC7A engagement and triggers an intracellular Ca2+ flux. SYK and Src family kinases are upstream of PLCG2 (Xu et al. 2009, Tassi et al. 2009, Gorjestani et al. 2011). SYK phosphorylates PLCG2 on Y753 and Y759, enhancing the activity of PLCG2 (Suzuki-Inoue et al. 2004).
Literature References
PubMed ID Title Journal Year
14656219 Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites

Auger, JM, Suzuki-Inoue, K, Rhee, SG, Watson, SP, Wilde, JI, Andrews, RK, Sekiya, F, Siraganian, RP

Biochem J 2004
19136564 Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells

Xu, S, Huo, J, Lam, KP, Kurosaki, T, Lee, KG

J. Biol. Chem. 2009
Participants
Catalyst Activity

protein tyrosine kinase activity of 1,3-beta-D-glucan:p-Y15-Clec7a:Syk [plasma membrane]

Orthologous Events
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