assembly of IftB complex

Stable Identifier
R-MMU-5617824
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
assembly of IftB complex

Localization and IP studies of mouse FLAG-tagged IFT B components in mouse cells demonstrates that, as in Chlamydomonas reinhardtii and Caenorhabditis elegans, Ift52, Ift74, Ift81, Ift88, Hspb11/Ift25, Ift46, Ift20, Traf3ip1/Ift54, Ift80, Ift27 and Rabl5/Ift22 localize to the cilium and likely form a conserved Ift B complex (Follit et al, 2009; Piperno and Mead, 1997; Cole et al, 1998; Cole, 2003; Ou et al, 2007; reviewed in Taschner et al, 2012). Based on sequence identity and biochemical and genetic studies, mouse Ift172 is likely also a member of the Ift B complex, despite the failure of the tagged protein to colocalize and interact with other Ift B proteins (Follit et al, 2009). The details of how and when the Ift B complex assembles and is regulated are not represented in this reaction.

Literature References
PubMed ID Title Journal Year
9114011 Transport of a novel complex in the cytoplasmic matrix of Chlamydomonas flagella

Piperno, G, Mead, K

Proc. Natl. Acad. Sci. U.S.A. 1997
19253336 Characterization of mouse IFT complex B

Follit, JA, Xu, F, Keady, BT, Pazour, GJ

Cell Motil. Cytoskeleton 2009
12795688 The intraflagellar transport machinery of Chlamydomonas reinhardtii

Cole, DG

Traffic 2003
17314406 Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles

Ou, G, Koga, M, Blacque, OE, Murayama, T, Ohshima, Y, Schafer, JC, Li, C, Yoder, BK, Leroux, MR, Scholey, JM

Mol. Biol. Cell 2007
9585417 Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons

Cole, DG, Diener, DR, Himelblau, AL, Beech, PL, Fuster, JC, Rosenbaum, JL

J. Cell Biol. 1998
22118932 Architecture and function of IFT complex proteins in ciliogenesis

Taschner, M, Bhogaraju, S, Lorentzen, E

Differentiation 2012
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