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Ezh2 [nucleoplasm]
Stable Identifier
R-MMU-5617899
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
Histone-lysine N-methyltransferase EZH2 ecNumber2.1.1.43/ecNumber, EZH2_MOUSE
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular Senescence (Mus musculus)
Oxidative Stress Induced Senescence (Mus musculus)
Formation of PRC2-EZH2 complex (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
Chromatin organization (Mus musculus)
Chromatin modifying enzymes (Mus musculus)
PKMTs methylate histone lysines (Mus musculus)
PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
Epigenetic regulation of gene expression (Mus musculus)
PRC2 methylates histones and DNA (Mus musculus)
DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Mus musculus)
DNMT1,3A,3B:PRC2:Chromatin (5-mC, H3K27me3) [nucleoplasm] (Mus musculus)
PRC2:Chromatin (5-methylcytosine, H3K27me3) [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Mus musculus)
PRC2 Core:Chromatin [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
PRC2 recruits DNA methyltransferases (Mus musculus)
DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Mus musculus)
PRC2 Core:Chromatin [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
PRC2 Core:Chromatin [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
PRC2 trimethylates histone H3 at lysine-27 (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
PRC2:Chromatin (H3K27me3) [nucleoplasm] (Mus musculus)
PRC2 [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
PRC2:JARID2:MTF2 [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
PRC2:PHF1 [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
PRC2:PHF19 [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
PRC2:Chromatin [nucleoplasm] (Mus musculus)
PRC2 [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
PRC2:JARID2:MTF2 [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
PRC2:PHF1 [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
PRC2:PHF19 [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by E2F6 (Mus musculus)
E2F6:TFDP1:EPC1 binds the PRC2 complex (Mus musculus)
E2F6:TFDP1:EPC1:PRC2 (EZH2) core [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
PTEN Regulation (Mus musculus)
Regulation of PTEN gene transcription (Mus musculus)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Mus musculus)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Mus musculus)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Mus musculus)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
Ezh2 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q61188 Ezh2
Gene Names
Ezh2, Enx1h
Chain
chain:1-746
Reference Genes
BioGPS Gene:14056 Ezh2
ENSEMBL:ENSMUSG00000029687 Ezh2
KEGG Gene (Mus musculus):14056 Ezh2
Monarch:14056 Ezh2
NCBI Gene:14056 Ezh2
UCSC:Q61188 Ezh2
Reference Transcript
RefSeq:NM_007971.2 Ezh2
Other Identifiers
10544501
14056
1416544_at
17466507
4340738
4407662
4485025
4533072
4580188
4650955
4658677
4668491
4681112
4748591
4836382
4864243
4869780
4984130
5065962
5167675
5238027
5255425
5269374
5286280
5316038
5317883
5361254
5361945
5414392
5512656
5592799
99917_at
A_55_P2041397
A_55_P2619322
A_55_P2619332
A_55_P2619337
GE1546389
GO:0000082
GO:0000122
GO:0000278
GO:0000781
GO:0000785
GO:0000976
GO:0000978
GO:0000979
GO:0001222
GO:0001932
GO:0002376
GO:0003012
GO:0003677
GO:0003682
GO:0003714
GO:0003723
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005677
GO:0005694
GO:0005721
GO:0005737
GO:0006306
GO:0006310
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0006954
GO:0008168
GO:0008284
GO:0009913
GO:0010468
GO:0010629
GO:0010718
GO:0014013
GO:0014834
GO:0014898
GO:0016279
GO:0016570
GO:0016740
GO:0018024
GO:0021695
GO:0021766
GO:0023052
GO:0030097
GO:0030154
GO:0030183
GO:0030216
GO:0031490
GO:0031507
GO:0031509
GO:0032200
GO:0032259
GO:0032355
GO:0034244
GO:0035098
GO:0035984
GO:0036211
GO:0036333
GO:0042054
GO:0042127
GO:0042752
GO:0043021
GO:0043226
GO:0043406
GO:0043433
GO:0043547
GO:0043565
GO:0045120
GO:0045202
GO:0045605
GO:0045617
GO:0045814
GO:0045892
GO:0046976
GO:0048387
GO:0048511
GO:0048856
GO:0048863
GO:0050767
GO:0051154
GO:0051932
GO:0070301
GO:0070314
GO:0070734
GO:0070878
GO:0071168
GO:0071707
GO:0071902
GO:0090183
GO:0097421
GO:0098532
GO:0106222
GO:0140096
GO:0140110
GO:0140718
GO:0140951
GO:1900006
GO:1900016
GO:1902808
GO:1904772
GO:1990841
GO:2000134
GO:2000737
ILMN_1234171
ILMN_2606429
ILMN_2988572
U52951_s_at
mMC016467
Participates
as a component of
PRC2 (EZH2) [nucleoplasm] (Mus musculus)
PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
as an input of
Formation of PRC2-EZH2 complex (Mus musculus)
Inferred From
EZH2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_031997.2
Ensembl
ENSMUST00000081721
,
ENSMUSP00000090318
,
ENSMUSP00000080419
,
ENSMUST00000092648
,
ENSMUSG00000029687
PRO
Q61188
MGI
107940
PDB
2QXV
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q921E6 Eed
2
Eed [nucleoplasm]
(R-MMU-5617986)
Eed [nucleoplasm]
(R-MMU-212278)
0.858
10
UniProt:Q80U70 Suz12
3
Suz12 [nucleoplasm]
(R-MMU-4615932)
Suz12 [nucleoplasm]
(R-MMU-5617919)
Suz12 [nucleoplasm]
(R-MMU-212217)
0.803
10
UniProt:Q62315
1
Jarid2 [nucleoplasm]
(R-MMU-2160949)
0.774
15
UniProt:Q9CWR8 Dnmt3l
1
Dnmt3l [nucleoplasm]
(R-MMU-5334127)
0.632
10
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.591
5
UniProt:Hoxc12 ENSMUSG00000050328
0.564
2
UniProt:O09106 Hdac1
2
Hdac1 [nucleoplasm]
(R-MMU-4616030)
Hdac1 [nucleoplasm]
(R-MMU-573340)
0.527
5
UniProt:P13864 Dnmt1
3
monoSUMO1-K-DNMT1 [nucleoplasm]
(R-MMU-4655353)
Dnmt1 [nucleoplasm]
(R-MMU-573310)
DNMT1 [nucleoplasm]
(R-MMU-212181)
0.527
3
UniProt:Q02395
1
Mtf2 [nucleoplasm]
(R-MMU-5084119)
0.499
4
UniProt:O88508 Dnmt3a
3
monoSumo1-K-Dnmt3a [nucleoplasm]
(R-MMU-4655411)
Dnmt3a [nucleoplasm]
(R-MMU-4655420)
DNMT3A [nucleoplasm]
(R-MMU-212287)
0.499
3
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