Reactome | Ezh2 [nucleoplasm]

Ezh2 [nucleoplasm]

Stable Identifier

R-MMU-5617899

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Histone-lysine N-methyltransferase EZH2 ecNumber2.1.1.43/ecNumber, EZH2_MOUSE

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - PTEN Regulation (Mus musculus)
      - Regulation of PTEN gene transcription (Mus musculus)
        
        MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Mus musculus)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Mus musculus)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Mus musculus)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Mus musculus)
        
        PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
        
        Ezh2 [nucleoplasm] (Mus musculus)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Mus musculus)
        
        PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
        
        Ezh2 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q61188 Ezh2

Gene Names

Ezh2, Enx1h

Chain

chain:1-746

Reference Genes

BioGPS Gene:14056 Ezh2

ENSEMBL:ENSMUSG00000029687 Ezh2

KEGG Gene (Mus musculus):14056 Ezh2

Monarch:14056 Ezh2

NCBI Gene:14056 Ezh2

UCSC:Q61188 Ezh2

Reference Transcript

RefSeq:NM_007971.2 Ezh2

Other Identifiers

10544501

14056

1416544_at

17466507

4340738

4407662

4485025

4533072

4580188

4650955

4658677

4668491

4681112

4748591

4836382

4864243

4869780

4984130

5065962

5167675

5238027

5255425

5269374

5286280

5316038

5317883

5361254

5361945

5414392

5512656

5592799

99917_at

A_55_P2041397

A_55_P2619322

A_55_P2619332

A_55_P2619337

GE1546389

GO:0000082

GO:0000122

GO:0000278

GO:0000781

GO:0000785

GO:0000976

GO:0000978

GO:0000979

GO:0001222

GO:0001932

GO:0002376

GO:0003012

GO:0003677

GO:0003682

GO:0003714

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005677

GO:0005694

GO:0005721

GO:0005737

GO:0006306

GO:0006310

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0006954

GO:0008168

GO:0008284

GO:0009913

GO:0010468

GO:0010629

GO:0010718

GO:0014013

GO:0014834

GO:0014898

GO:0016279

GO:0016570

GO:0016740

GO:0018024

GO:0021695

GO:0021766

GO:0023052

GO:0030097

GO:0030154

GO:0030183

GO:0030216

GO:0031490

GO:0031507

GO:0031509

GO:0032200

GO:0032259

GO:0032355

GO:0034244

GO:0035098

GO:0035984

GO:0036211

GO:0036333

GO:0042054

GO:0042127

GO:0042752

GO:0043021

GO:0043226

GO:0043406

GO:0043433

GO:0043547

GO:0043565

GO:0045120

GO:0045202

GO:0045605

GO:0045617

GO:0045814

GO:0045892

GO:0046976

GO:0048387

GO:0048511

GO:0048856

GO:0048863

GO:0050767

GO:0051154

GO:0051932

GO:0070301

GO:0070314

GO:0070734

GO:0070878

GO:0071168

GO:0071707

GO:0071902

GO:0090183

GO:0097421

GO:0098532

GO:0106222

GO:0140096

GO:0140110

GO:0140718

GO:0140951

GO:1900006

GO:1900016

GO:1902808

GO:1904772

GO:1990841

GO:2000134

GO:2000737

ILMN_1234171

ILMN_2606429

ILMN_2988572

U52951_s_at

mMC016467

Participates

as a component of

as an input of

Formation of PRC2-EZH2 complex (Mus musculus)

Inferred From

EZH2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_031997.2

Ensembl

ENSMUST00000081721, ENSMUSP00000090318, ENSMUSP00000080419, ENSMUST00000092648, ENSMUSG00000029687

PRO

Q61188

MGI

107940

PDB

2QXV

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q921E6 Eed	2	Eed [nucleoplasm] (R-MMU-5617986) Eed [nucleoplasm] (R-MMU-212278)	0.858	10
UniProt:Q80U70 Suz12	3	Suz12 [nucleoplasm] (R-MMU-4615932) Suz12 [nucleoplasm] (R-MMU-5617919) Suz12 [nucleoplasm] (R-MMU-212217)	0.803	10
UniProt:Q62315	1	Jarid2 [nucleoplasm] (R-MMU-2160949)	0.774	15
UniProt:Q9CWR8 Dnmt3l	1	Dnmt3l [nucleoplasm] (R-MMU-5334127)	0.632	10
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.591	5
UniProt:Hoxc12 ENSMUSG00000050328			0.564	2
UniProt:O09106 Hdac1	2	Hdac1 [nucleoplasm] (R-MMU-4616030) Hdac1 [nucleoplasm] (R-MMU-573340)	0.527	5
UniProt:P13864 Dnmt1	3	monoSUMO1-K-DNMT1 [nucleoplasm] (R-MMU-4655353) Dnmt1 [nucleoplasm] (R-MMU-573310) DNMT1 [nucleoplasm] (R-MMU-212181)	0.527	3
UniProt:Q02395	1	Mtf2 [nucleoplasm] (R-MMU-5084119)	0.499	4
UniProt:O88508 Dnmt3a	3	monoSumo1-K-Dnmt3a [nucleoplasm] (R-MMU-4655411) Dnmt3a [nucleoplasm] (R-MMU-4655420) DNMT3A [nucleoplasm] (R-MMU-212287)	0.499	3

Cite Us!