Reactome: A Curated Pathway Database

Hoxb1 gene is transcribed

Stable Identifier
Reaction [BlackBoxEvent]
Mus musculus

The Hoxb1 gene is transcribed to yield mRNA (Marshall et al. 1994, Studer et al. 1994, Ogura and Evans 1995, Chiba et al. 1997, Di Rocco et al. 1997, Langston et al. 1997, Wendling et al. 2001, Huang et al. 2002, Roelen et al. 2002).
Hoxb1 is expressed in mesoderm and neurectoderm of primitive streak stage embryos and then becomes restricted to rhombomeres of the hindbrain (Murphy et al. 1989, Wilkinson et al. 1989, Bogue et al. 1996). Before rhombomere formation Hoxb1 is initially expressed in the region that becomes r3-7. After rhombomere formation Hoxb1 becomes restricted to r4 and is also observed in caudal mesoderm (Murphy et al. 1989, Arenkiel et al. 2003).

Literature References
PubMed ID Title Journal Year
15654074 MEIS C termini harbor transcriptional activation domains that respond to cell signaling J. Biol. Chem. 2005
9154799 Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells Mol. Cell. Biol. 1997
7831297 Evidence for two distinct retinoic acid response pathways for HOXB1 gene regulation Proc. Natl. Acad. Sci. U.S.A. 1995
7831296 A retinoic acid-triggered cascade of HOXB1 gene activation Proc. Natl. Acad. Sci. U.S.A. 1995
8703472 Expression of Hoxb genes in the developing mouse foregut and lung Am. J. Respir. Cell Mol. Biol. 1996
12815623 Hoxb1 neural crest preferentially form glia of the PNS Dev. Dyn. 2003
2571936 Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain Nature 1989
7916164 Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1 Science 1994
7914354 A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1 Nature 1994
9218805 Functional dissection of a transcriptionally active, target-specific Hox-Pbx complex EMBO J. 1997
21320481 Hoxb3 negatively regulates Hoxb1 expression in mouse hindbrain patterning Dev. Biol. 2011
12385756 Hox cluster polarity in early transcriptional availability: a high order regulatory level of clustered Hox genes in the mouse Mech. Dev. 2002
11891985 Analysis of two distinct retinoic acid response elements in the homeobox gene Hoxb1 in transgenic mice Dev. Dyn. 2002
8999919 Retinoic acid-responsive enhancers located 3' of the Hox A and Hox B homeobox gene clusters. Functional analysis J. Biol. Chem. 1997
2571087 Segment-specific expression of a homoeobox-containing gene in the mouse hindbrain Nature 1989
11493525 Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning Development 2001
11278854 The recruitment of SOX/OCT complexes and the differential activity of HOXA1 and HOXB1 modulate the Hoxb1 auto-regulatory enhancer function J. Biol. Chem. 2001
This entity is regulated by:
Orthologous Events