Reactome: A Curated Pathway Database

Hoxa1 gene is transcribed

Stable Identifier
Reaction [BlackBoxEvent]
Mus musculus

The Hoxa1 gene is transcribed to yield mRNA in response to retinoic acid in embryos (Frasch et al. 1995, Dupe et al. 1997), teratocarcinoma cells (Langston and Gudas 1992, Langston et al. 1997, Lee et al. 1997, Kashyap and Gudas 2010), and embryonic stem cells (Chen and Reese 2011, reviewed in Gudas and Wagner 2011). Hoxa1 mRNA is observed in the neural tube, adjacent mesenchyme, paraxial mesoderm, somites, and gut epithelium from rhombomere 4 to the caudal-most region of the embryo (Baron et al. 1987, Sundin et al, 1990, Murphy and Hill 1991, Godwin et al. 1998, Makki and Capecchi 2010). (Rhombomeres are transiently formed segments in the neural tube that will eventually form the hindbrain.)
The long non-coding RNA linc-HOXA1 suppresses transcription of Hoxa1 in embryonic stem cells (Maamar et al. 2013).

Literature References
PubMed ID Title Journal Year
17525233 High histone acetylation and decreased polycomb repressive complex 2 member levels regulate gene specific transcriptional changes during early embryonic stem cell differentiation induced by retinoic acid Stem Cells 2007
1693558 Region-specific expression in early chick and mouse embryos of Ghox-lab and Hox 1.6, vertebrate homeobox-containing genes related to Drosophila labial Development 1990
1673098 Expression of the mouse labial-like homeobox-containing genes, Hox 2.9 and Hox 1.6, during segmentation of the hindbrain Development 1991
9053316 In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE) Development 1997
20836077 Retinoids regulate stem cell differentiation J. Cell. Physiol. 2011
21618588 The retinol signaling pathway in mouse pluripotent P19 cells J. Cell. Biochem. 2011
7743939 Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila Development 1995
20231276 Epigenetic regulatory mechanisms distinguish retinoic acid-mediated transcriptional responses in stem cells and fibroblasts J. Biol. Chem. 2010
20171203 Hoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere Dev. Biol. 2010
1360810 Identification of a retinoic acid responsive enhancer 3' of the murine homeobox gene Hox-1.6 Mech. Dev. 1992
23723417 linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in cis Genes Dev. 2013
9789037 Detection of targeted GFP-Hox gene fusions during mouse embryogenesis Proc. Natl. Acad. Sci. U.S.A. 1998
2891503 Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1 complex EMBO J. 1987
8999919 Retinoic acid-responsive enhancers located 3' of the Hox A and Hox B homeobox gene clusters. Functional analysis J. Biol. Chem. 1997
This entity is regulated by:
Orthologous Events