Hoxa4 gene is transcribed

Stable Identifier
R-MMU-5619414
Type
Reaction [BlackBoxEvent]
Species
Mus musculus
Compartment
Summation

The Hoxa4 gene is transcribed to yield mRNA (Behringer et al. 1993, Packer et al. 1998, Packer et al. 2000). MicroRNAs miR-196a-2, miR-196b, and miRNA miR-222 target Hoxa4 mRNA untranslated regions (Arnold et al. 2011). Hoxa4 mRNA is observed in rhombomere 7 (Morrison et al. 1997), mesoderm including somites, lung, and kidney (Behringer et al. 1993, Packer et al 1998, Packer et al. 2000), rostral-dorsal stomach, rostral prececal gut, and large intestine (Pitera et al. 1999).

Literature References
PubMed ID Title Journal Year
10579975 Coordinated expression of 3' hox genes during murine embryonal gut development: an enteric Hox code

Pitera, JE, Smith, VV, Thorogood, P, Milla, PJ

Gastroenterology 1999
9272954 HOXD4 and regulation of the group 4 paralog genes

Morrison, A, Ariza-McNaughton, L, Gould, A, Featherstone, M, Krumlauf, R

Development 1997
10679930 Regulation of the Hoxa4 and Hoxa5 genes in the embryonic mouse lung by retinoic acid and TGFbeta1: implications for lung development and patterning

Packer, AI, Mailutha, KG, Ambrozewicz, LA, Wolgemuth, DJ

Dev. Dyn. 2000
9570764 Expression of the murine Hoxa4 gene requires both autoregulation and a conserved retinoic acid response element

Packer, AI, Crotty, DA, Elwell, VA, Wolgemuth, DJ

Development 1998
21451113 MicroRNA programs in normal and aberrant stem and progenitor cells

Arnold, CP, Tan, R, Zhou, B, Yue, SB, Schaffert, S, Biggs, JR, Doyonnas, R, Lo, MC, Perry, JM, Renault, VM, Sacco, A, Somervaille, T, Viatour, P, Brunet, A, Cleary, ML, Li, L, Sage, J, Zhang, DE, Blau, HM, Chen, C, Chen, CZ

Genome Res. 2011
8100763 Sequences 5' of the homeobox of the Hox-1.4 gene direct tissue-specific expression of lacZ during mouse development

Behringer, RR, Crotty, DA, Tennyson, VM, Brinster, RL, Palmiter, RD, Wolgemuth, DJ

Development 1993
7901228 Protein product of the somatic-type transcript of the Hoxa-4 (Hox-1.4) gene binds to homeobox consensus binding sites in its promoter and intron

Wu, K, Wolgemuth, DJ

J. Cell. Biochem. 1993
Participants
This entity is regulated by
Orthologous Events
Authored
Reviewed